Most neurodegenerative disorders have complex and still unresolved pathology
characterized by progressive neuronal damage and death. Astrocytes, the most-abundant …

Astrocytes have a central role in brain development and function, and so have gained
increasing attention over the past two decades. Consequently, our knowledge about their …

Astrocytes play a number of key functions in health and disease. Activated astrocytes are
present in most, if not all, neurological diseases. Most current information on the …

To an increasing extent, astrocytes are connected with various neuropathologies. Astrocytes
comprise of a heterogeneous population of cells with region-and species-specific properties …

Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an
organism's somatic cells. These can then be programmed to other cell types, including …

Astrocytes are the most abundant cell type in the brain. They were long considered only as
passive support for neuronal cells. However, recent data have revealed many active roles …

Accumulating studies demonstrate the morphological and functional diversity of astrocytes, a
subtype of glial cells in the central nervous system. Animal models are instrumental in …

Based on investigations, there exist tight correlations between neurodegenerative diseases'
incidence and progression and aberrant protein aggregreferates in nervous tissue …

Introduction Astrocytes are glial-type cells that protect neurons from toxic insults and support
neuronal functions and metabolism in a healthy brain. Leveraging these physiological …

Induced pluripotent stem cell (iPSC)-based disease modeling has a great potential for
uncovering the mechanisms of pathogenesis, especially in the case of neurodegenerative …