[HTML][HTML] Anti-inflammatory and immunoregulatory effects of icariin and icaritin

Z Bi, W Zhang, X Yan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Inflammation and immunity dysregulation have received widespread attention in recent
years due to their occurrence in the pathophysiology of many conditions. In this regard …

[HTML][HTML] The effect of icariin on immunity and its potential application

R Shen, JH Wang - American journal of clinical and experimental …, 2018 - ncbi.nlm.nih.gov
Icariin (ICA) is a major bioactive monomer belonging to flavonoid glycosides attracted from
Epimedium, being a classic tonic agent in traditional Chinese medicine. ICA commonly …

Impact of Icariin and its derivatives on inflammatory diseases and relevant signaling pathways

Z Luo, J Dong, J Wu - International Immunopharmacology, 2022 - Elsevier
Herba Epimedii is a famous herb collected from China and Korea. It has been used for
impotency, osteoporosis, and amnestic treatment for thousands of years. Icariin, a typical …

Pharmacological effects of icariin

C He, Z Wang, J Shi - Advances in pharmacology, 2020 - Elsevier
Icariin (ICA) is a principal active component from traditional Chinese medicine Epimedium
grandiflorum. To explain its traditional medical usages by modern science, a variety of …

Icaritin exhibits anti-inflammatory effects in the mouse peritoneal macrophages and peritonitis model

X Lai, Y Ye, C Sun, X Huang, X Tang, X Zeng… - International …, 2013 - Elsevier
Icaritin, an intestinal metabolite of prenylflavonoids from Herba Epimedii, has been known to
regulate many cellular processes. The purpose of this study was to investigate the protective …

Icariin inhibits TNF-α/IFN-γ induced inflammatory response via inhibition of the substance P and p38-MAPK signaling pathway in human keratinocytes

L Kong, J Liu, J Wang, Q Luo, H Zhang, B Liu… - International …, 2015 - Elsevier
Pro-inflammatory cytokines play a crucial role in the etiology of atopic dermatitis. We
demonstrated that Herba Epimedii has anti-inflammatory potential in an atopic dermatitis …

Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-κb pathways

SR Chen, XZ Xu, YH Wang, JW Chen… - Biological and …, 2010 - jstage.jst.go.jp
In this study we investigated the anti-inflammatory effects of an icariin derivative (3, 5-
dihydroxy-4-methoxy-6, 6-dimethy1-4, 5-dihydropyrano [2, 3: 7, 8]-flavone). We found that …

Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions

J Zhou, J Wu, X Chen, N Fortenbery, E Eksioglu… - International …, 2011 - Elsevier
3, 5, 7-Trihydroxy-4′-methoxy-8-(3-hydroxy-3-methylbutyl)-flavone (ICT) is a novel
derivative of Icariin (ICA), the major active ingredient of Herba Epimedii, a herb used in …

[HTML][HTML] Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways

NA El-Shitany, BG Eid - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Cellular inflammation has been recognized as the leading factor in numerous diseases,
causing either cell death, organ-specific damage, or genesis of different cancers. Icariin, a …

Bioavailability improvement strategies for icariin and its derivates: A review

R Szabó, CP Rácz, FV Dulf - International Journal of Molecular Sciences, 2022 - mdpi.com
In recent years, there has been considerable interest in icariin (ICA) and its derivates,
icariside II (ICS) and icaritin (ICT), due to their wide range of potential applications in …