There is a dearth of chemical inhibitors of connexin-mediated intercellular communication.
The advent of short “designer” connexin mimetic peptides has provided new tools to inhibit …

Intercellular co-operation is a fundamental and widespread feature in tissues and organs.
An important mechanism ensuring multicellular homoeostasis involves signalling between …

Connexin mimetic peptides corresponding to short conserved extracellular loop sequences
of connexins have been used widely as reversible inhibitors of gap junctional intercellular …

Connexins form gap junctions that function as intercellular channels and hemichannels that
form a conduit between the cytoplasm and extracellular fluid when open. Peptide inhibitors …

Gap junctions (GJ) and connexins play integral roles in cellular physiology and have been
found to be involved in multiple pathophysiological states from cancer to cardiovascular …

Connexin hemichannels, that is, half gap junction channels (not connecting cells), have
been implicated in the release of various messengers such as ATP and glutamate. We used …

Connexin mimetic peptides are widely used to assess the contribution of nonjunctional
connexin channels in several processes, including ATP release. These peptides are derived …

Abstract Background Non-selective Connexin43 hemichannels contribute to secondary
lesion spread. The hemichannel blocking peptidomimetic Peptide5, derived from the second …

Gap junctions are key components underpinning multicellularity. They provide cell to cell
channel pathways that enable direct intercellular communication and cellular coordination in …

Connexins, in particular connexin 43 (Cx43), function as gap junction channels (GJCs) and
hemichannels (HCs). Only recently, specific tools have been developed to study their …