Detection of cytosolic DNA constitutes a central event in the context of numerous infectious
and sterile inflammatory conditions. Recent studies have uncovered a bipartite mode of …

Viral infection triggers host innate immune responses that result in the production of various
cytokines including type I interferons (IFN), activation of inflammasomes, and programmed …

The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of
the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to …

Inflammasomes are critical sensors that convey cellular stress and pathogen presence to the
immune system by activating inflammatory caspases and cytokines such as IL-1β. The …

The sensing of viral nucleic acids within the cytosol is essential for the induction of innate
immune responses following infection. However, this sensing occurs within cells that have …

Cytoplasmic DNA triggers activation of the innate immune system. Although'downstream'
signaling components have been characterized, the DNA-sensing components remain …

The innate immune system recognizes nucleic acids during infection and tissue damage.
Whereas viral RNA is detected by endosomal toll-like receptors (TLR3, TLR7, TLR8) and …

The innate immune system responds to infection and tissue damage by activating cytosolic
sensory complexes called'inflammasomes'. Cytosolic DNA is sensed by AIM2-like receptors …

Germline-encoded pattern recognition receptors (PRRs) sense microbial or endogenous
products released from damaged or dying cells and trigger innate immunity. In most cases …

Recent evidence has indicated that innate immune sensing of cytosolic DNA in dendritic
cells via the host STING pathway is a major mechanism leading to spontaneous T cell …