The construction of a predictive model of an entire eukaryotic cell that describes its dynamic
structure from atomic to cellular scales is a grand challenge at the intersection of biology …

Background Despite decades of new discoveries in biomedical research, the overwhelming
complexity of cells has been a significant barrier to a fundamental understanding of how …

Rule-based modeling has become a powerful approach for modeling intracellular networks,
which are characterized by rich molecular diversity. Truly comprehensive models of cell …

Whole-cell dynamical models of human cells are a central goal of systems biology. Such
models could help researchers understand cell biology and help physicians treat disease …

Cellular metabolism continuously processes an enormous range of external compounds into
endogenous metabolites and is as such a key element in human physiology. The …

Comprehensive modeling of a whole cell requires an integration of vast amounts of
information on various aspects of the cell and its parts. To divide and conquer this task, we …

Gaining knowledge and engineering of biological systems require comprehensive models of
cellular physiology with 100% predictability. The whole-cell models direct experiments in …

The reductionist movement of twentieth century biological science successfully used the
tools of biochemistry, molecular biology, and structural biology to provide us with an …

Modeling approaches to the dynamics of a living cell are presented that are strongly based
on its underlying physical and chemical processes and its hierarchical spatio-temporal …

Background Models of metabolism are often used in biotechnology and pharmaceutical
research to identify drug targets or increase the direct production of valuable compounds …