Directed differentiation of human pluripotent stem cells to kidney organoids brings the
prospect of drug screening, disease modelling and the generation of tissue for renal …

The kidney is a vital organ that regulates the bodily fluid and electrolyte homeostasis via
tailored urinary excretion. Kidney injuries that cause severe or progressive chronic kidney …

Kidney organoids derived from human induced pluripotent stem cells bear the potential to
be used as a regenerative medicine renal replacement therapy. Advances in developmental …

Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-
throughput screening (HTS), but the complexity of organoid cultures poses a significant …

A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …

Kidney organoids made from pluripotent stem cells have the potential to revolutionize how
kidney development, disease, and injury are studied. Current protocols are technically …

The generation of organoids is one of the biggest scientific advances in regenerative
medicine. Here, by lengthening the time that human pluripotent stem cells (hPSCs) were …

The utility of human pluripotent stem cell–derived kidney organoids relies implicitly on the
robustness and transferability of the protocol. Here we analyze the sources of transcriptional …

The number of patients with end-stage renal disease is continuously increasing worldwide.
The only therapies for these patients are dialysis and organ transplantation, but the latter is …

The kidney is a highly complex organ in the human body. Although creating an in vitro
model of the human kidney is challenging, tremendous advances have been made in recent …