[HTML][HTML] Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

R Singh, S Chandrashekharappa, SR Bodduluri… - Nature …, 2019 - nature.com
The importance of gut microbiota in human health and pathophysiology is undisputable.
Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in …

[HTML][HTML] Gut-resident lactobacilli activate hepatic Nrf2 and protect against oxidative liver injury

BJ Saeedi, KH Liu, JA Owens, S Hunter-Chang… - Cell metabolism, 2020 - cell.com
Many studies have suggested a role for gut-resident microbes (the" gut microbiome") in
modulating host health; however, the mechanisms by which they impact systemic physiology …

Redox signaling mediated by the gut microbiota

RM Jones, AS Neish - Free Radical Biology and Medicine, 2017 - Elsevier
The microbiota that inhabits the mammalian intestine can influence a range of physiological
functions, including the modulation of immune responses, enhancement epithelial barrier …

[HTML][HTML] Regulation of intestinal barrier function by microbial metabolites

S Ghosh, CS Whitley, B Haribabu, VR Jala - Cellular and molecular …, 2021 - Elsevier
The human gastrointestinal tract (GI) harbors a diverse population of microbial life that
continually shapes host pathophysiological responses. Despite readily available abundant …

Reactive oxygen production induced by the gut microbiota: pharmacotherapeutic implications

RM Jones, JW Mercante… - Current medicinal …, 2012 - ingentaconnect.com
The resident prokaryotic microbiota of the mammalian intestine influences diverse
homeostatic functions, including regulation of cellular growth, maintenance of barrier …

Urolithin A alleviates colitis in mice by improving gut microbiota dysbiosis, modulating microbial tryptophan metabolism, and triggering AhR activation

M Ma, Y Wang, S Fan, Y Huang, X Su… - Journal of Agricultural …, 2023 - ACS Publications
Urolithin A (UroA) is a microbial metabolite derived from ellagitannins and ellagic acid with
good bioavailability. In this study, we explored the anticolitis activity of UroA and clarified the …

[HTML][HTML] Redox signaling regulates commensal-mediated mucosal homeostasis and restitution and requires formyl peptide receptor 1

A Alam, G Leoni, CC Wentworth, JM Kwal, H Wu… - Mucosal …, 2014 - nature.com
The mammalian gut microbiota is essential for normal intestinal development, renewal, and
repair. Injury to the intestinal mucosa can occur with infection, surgical trauma, and in …

[HTML][HTML] Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling

M Levy, CA Thaiss, D Zeevi, L Dohnalová… - Cell, 2015 - cell.com
Host-microbiome co-evolution drives homeostasis and disease susceptibility, yet regulatory
principles governing the integrated intestinal host-commensal microenvironment remain …

[HTML][HTML] Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis

J Wu, Z Wei, P Cheng, C Qian, F Xu, Y Yang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Gut microbiota, which plays a crucial role in inflammatory bowel diseases
(IBD), might have therapeutic benefits for ulcerative colitis or Crohn's disease. Targeting gut …

[HTML][HTML] Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier

L Hoyles, T Snelling, UK Umlai, JK Nicholson… - Microbiome, 2018 - Springer
Background Gut microbiota composition and function are symbiotically linked with host
health and altered in metabolic, inflammatory and neurodegenerative disorders. Three …