[HTML][HTML] Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses

JT Ladner, SN Henson, AS Boyle… - Cell Reports …, 2021 - cell.com
The SARS-CoV-2 proteome shares regions of conservation with endemic human
coronaviruses (CoVs), but it remains unknown to what extent these may be cross …

Epitope profiling reveals binding signatures of SARS-CoV-2 immune response in natural infection and cross-reactivity with endemic human CoVs

CI Stoddard, J Galloway, HY Chu, MM Shipley, K Sung… - Cell Reports, 2021 - cell.com
A major goal of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccine efforts is to elicit antibody responses that confer protection. Mapping the epitope …

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

E Shrock, E Fujimura, T Kula, RT Timms, IH Lee… - Science, 2020 - science.org
INTRODUCTION A systematic characterization of the humoral response to severe acute
respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This …

The landscape of antibody binding in SARS-CoV-2 infection

AS Heffron, SJ McIlwain, MF Amjadi, DA Baker… - PLoS …, 2021 - journals.plos.org
The search for potential antibody-based diagnostics, vaccines, and therapeutics for
pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has focused …

Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccination

ES Geanes, C LeMaster, ER Fraley, S Khanal… - Scientific Reports, 2022 - nature.com
SARS-CoV-2 is a novel betacoronavirus that caused coronavirus disease 2019 and has
resulted in millions of deaths worldwide. Novel coronavirus infections in humans have …

Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination

TG Caniels, I Bontjer, K van der Straten, M Poniman… - Science …, 2021 - science.org
Emerging SARS-CoV-2 variants of concern (VOCs) pose a threat to human immunity
induced by natural infection and vaccination. We assessed the recognition of three VOCs (B …

Cross-reactive antibodies against human coronaviruses and the animal coronavirome suggest diagnostics for future zoonotic spillovers

S Klompus, S Leviatan, T Vogl, RD Mazor… - Science …, 2021 - science.org
The spillover of animal coronaviruses (aCoVs) to humans has caused SARS, MERS, and
COVID-19. Although antibody responses displaying cross-reactivity between SARS-CoV-2 …

High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

WA Haynes, K Kamath, J Bozekowski… - Communications …, 2021 - nature.com
Abstract As Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to
spread, characterization of its antibody epitopes, emerging strains, related coronaviruses …

SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus

M Dogan, L Kozhaya, L Placek, C Gunter… - Communications …, 2021 - nature.com
Abstract Development of antibody protection during SARS-CoV-2 infection is a pressing
question for public health and for vaccine development. We developed highly sensitive …

[HTML][HTML] A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2

A Majdoubi, C Michalski, SE O'Connell, S Dada… - JCI insight, 2021 - ncbi.nlm.nih.gov
Preexisting cross-reactivity to SARS-CoV-2 occurs in the absence of prior viral exposure.
However, this has been difficult to quantify at the population level due to a lack of reliably …