Molecular mechanisms of glioma cell migration and invasion

T Demuth, ME Berens - Journal of neuro-oncology, 2004 - Springer
Gliomas are the most common intracranial tumors. In the US, approximately 15,000 patients
die with glioblastoma per year (CBTRUS 2002). Despite modern diagnostics and treatments …

Molecular targets of glioma invasion

M Nakada, S Nakada, T Demuth, NL Tran… - Cellular and molecular …, 2007 - Springer
Glioblastoma multiforme is the most common and lethal primary malignant brain tumor.
Although considerable progress has been made in technical proficiencies of surgical and …

Molecular mechanisms of glioma cell motility

A Armento, J Ehlers, S Schötterl… - Exon …, 2017 - exonpublications.com
Gliomas are the most common intracranial tumors in humans. The most malignant among
these tumors is glioblastoma (GBM), with an incidence of 3–5 out of 100,000 persons in …

Biological mechanisms of glioma invasion and potential therapeutic targets

B Bølge Tysnes, R Mahesparan - Journal of neuro-oncology, 2001 - Springer
The current understanding of glioma biology reveals targets for anti-invasive therapy which
include manipulations of extracellular matrix and receptors, growth factors and cytokines …

“... those left behind.” Biology and oncology of invasive glioma cells

ME Berens, A Giese - Neoplasia, 1999 - Elsevier
Although significant technical advances in surgical and radiation treatment for brain tumors
have emerged in recent years, their impact on clinical outcome for patients has been …

[PDF][PDF] Cost of migration: invasion of malignant gliomas and implications for treatment

A Giese, R Bjerkvig, ME Berens, M Westphal - Journal of clinical oncology, 2003 - uksh.de
Tumors of glial origin consist of a core mass and a penumbra of invasive, single cells,
decreasing in numbers towards the periphery and still detectable several centimeters away …

Mechanisms regulating glioma invasion

I Paw, RC Carpenter, K Watabe, W Debinski, HW Lo - Cancer letters, 2015 - Elsevier
Glioblastoma (GBM) is the most aggressive, deadliest, and most common brain malignancy
in adults. Despite the advances made in surgical techniques, radiotherapy and …

Tumor cell infiltration into the brain in glioblastoma: from mechanisms to clinical perspectives

F Seker-Polat, N Pinarbasi Degirmenci, I Solaroglu… - Cancers, 2022 - mdpi.com
Simple Summary The estimated survival time for glioblastoma patients is extremely low; only
about 5% of patients survive five years post diagnosis. The standard of care for glioblastoma …

Tumor cell invasion in glioblastoma

A Vollmann-Zwerenz, V Leidgens, G Feliciello… - International journal of …, 2020 - mdpi.com
Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16
months. Recent research has revealed novel insights into the outstanding heterogeneity of …

A neurocentric perspective on glioma invasion

VA Cuddapah, S Robel, S Watkins… - Nature Reviews …, 2014 - nature.com
Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …