In the past few decades, as a result of their anti-inflammatory properties, n-3 long chain
polyunsaturated fatty acids (n-3 LC-PUFAs), have gained greater importance in the …

Aging is associated to cognitive decline, which can lead to loss of life quality, personal
suffering, and ultimately neurodegenerative diseases. Neuroinflammation is one of the …

Neuroinflammation is present in the majority of acute and chronic neurological disorders.
Excess or prolonged inflammation in the brain is thought to exacerbate neuronal damage …

Inflammation has been identified as one of the main pathophysiological mechanisms
underlying neuropsychiatric and neurodegenerative disorders. Despite the role of …

Inflammation is involved in the pathophysiology of many chronic diseases, such as
rheumatoid arthritis and neurodegenerative diseases. Several studies have evidenced …

Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Introduction 3. Metabolism of n-3 PUFA in the brain 3.1. Accumulation of n-3 PUFAs in the
brain 3.2. Turnover of n-3 PUFAs in the brain 4. n-3 PUFAs in cerebral ischemia 5. n-3 …

Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative disorders
that affect millions of individuals worldwide. As incidence of these conditions increases with …

The innate immune system of the brain is principally composed of microglial cells and
astrocytes, which, once activated, protect neurons against insults (infectious agents, lesions …

The brain is highly enriched with fatty acids. These include the polyunsaturated fatty acids
(PUFAs) arachidonic acid and docosahexaenoic acid, which are largely esterified to the …