Pharmacogenetics of postoperative nausea and vomiting

EN Aroke, TL Hicks - Journal of PeriAnesthesia Nursing, 2019 - Elsevier
Postoperative nausea and vomiting (PONV) remains one of the most common adverse
effects of anesthesia, affecting up to 80% of high-risk patients within 24 hours after surgery …

Is there a place for genetics in the management of PONV?

K Candiotti, C Shrestha, MRS Ceschim - Best Practice & Research Clinical …, 2020 - Elsevier
Antiemetic prophylaxis for postoperative nausea and vomiting (PONV)–a frequent
complication in the postoperative period–is routinely given to high-risk patients. However …

Genetic variability in postoperative nausea and vomiting: A systematic review

S Klenke, UH Frey - European Journal of Anaesthesiology| EJA, 2020 - journals.lww.com
BACKGROUND Postoperative nausea and vomiting (PONV) is the most frequent side effect
following anaesthesia. Predisposition to developing PONV is multifactorial with patient risk …

The impact of pharmacogenomics on postoperative nausea and vomiting: do CYP2D6 allele copy number and polymorphisms affect the success or failure of …

KA Candiotti, DJ Birnbach, DA Lubarsky… - The Journal of the …, 2005 - pubs.asahq.org
Background Some patients treated with ondansetron for postoperative nausea and vomiting
do not respond to therapy. One possible mechanism for this failure is ultrarapid drug …

Genetic contribution to PONV risk

S Klenke, GJ de Vries, L Schiefer, N Seyffert… - … Critical Care & Pain …, 2020 - Elsevier
Background Clinical risk factors for postoperative nausea and vomiting (PONV) are usually
stratified using the Apfel Score. While a genetic predisposition has recently been …

The association of CYP2D6 genotype and postoperative nausea and vomiting in orthopedic trauma patients

SW Wesmiller, RA Henker, SM Sereika… - … research for nursing, 2013 - journals.sagepub.com
The CYP2D6 gene encodes for an enzyme that is involved in the metabolism of more than
25% of all medications, including many opioids and antiemetics. It may contribute to the risk …

[HTML][HTML] CYP2D6 basic genotyping as a potential tool to improve the antiemetic efficacy of ondansetron in prophylaxis of postoperative nausea and vomiting

PA Niewiński, R Wojciechowski… - … in Clinical and …, 2018 - advances.umw.edu.pl
Background. Postoperative nausea and vomiting (PONV) is a common complication after
anesthesia and surgery. Ondansetron is one of the most widely used drugs in the …

Genetic factors associated with postoperative nausea and vomiting: a systematic review

P López-Morales, D Flores-Funes… - Journal of …, 2018 - Elsevier
Background In previous studies, there seems to be a relationship between different genetic
polymorphisms and postoperative nausea and vomiting (PONV). We perform a systematic …

Genome-wide association study using pooled DNA to identify candidate markers mediating susceptibility to postoperative nausea and vomiting

PK Janicki, R Vealey, J Liu, J Escajeda… - The Journal of the …, 2011 - pubs.asahq.org
Background A family history has been established as a risk factor for postoperative nausea
and vomiting (PONV), but the identities of susceptibility genes remain unknown. The goal of …

Genetic polymorphisms in the cytochrome P450 system and efficacy of 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting

M Nielsen, NV Olsen - British journal of anaesthesia, 2008 - academic.oup.com
Postoperative nausea and vomiting (PONV) is a frequent and distressing complication of
anaesthesia and surgery with an average incidence ranging between 20% and 30%, but up …