Toward understanding the cold, hot, and neutral nature of Chinese medicines using in silico mode-of-action analysis

X Fu, LH Mervin, X Li, H Yu, J Li… - Journal of chemical …, 2017 - ACS Publications
One important, however, poorly understood, concept of Traditional Chinese Medicine (TCM)
is that of hot, cold, and neutral nature of its bioactive principles. To advance the field, in this …

TCMAnalyzer: a chemo-and bioinformatics web service for analyzing traditional Chinese medicine

Z Liu, J Du, X Yan, J Zhong, L Cui, J Lin… - Journal of Chemical …, 2018 - ACS Publications
Traditional Chinese medicine (TCM) has been widely used and proven effective in long term
clinical practice. However, the molecular mechanism of action for many TCMs remains …

Chemogenomics approaches to rationalizing the mode-of-action of traditional Chinese and Ayurvedic medicines

F Mohd Fauzi, A Koutsoukas, R Lowe… - Journal of Chemical …, 2013 - ACS Publications
Traditional Chinese medicine (TCM) and Ayurveda have been used in humans for
thousands of years. While the link to a particular indication has been established in man, the …

Molecular network and chemical fragment-based characteristics of medicinal herbs with cold and hot properties from Chinese medicine

F Liang, L Li, M Wang, X Niu, J Zhan, X He, C Yu… - Journal of …, 2013 - Elsevier
Ethnopharmacological relevance Chinese herbal medicines (HMs) is one of the great herbal
systems of the world, which play an important role in current health care system in many …

In silico toxicity studies of traditional Chinese herbal medicine: a mini review

MH Zulkifli, ZL Abdullah, NISM Yusof… - Current Opinion in …, 2023 - Elsevier
With the availability of public databases that store compound-target/compound-toxicity
information, and Traditional Chinese medicine (TCM) databases, in silico approaches are …

Systems pharmacology for investigation of the mechanisms of action of traditional Chinese medicine in drug discovery

W Zhang, Y Huai, Z Miao, A Qian… - Frontiers in pharmacology, 2019 - frontiersin.org
As a traditional medical intervention in Asia and a complementary and alternative medicine
in western countries, traditional Chinese medicine (TCM) has attracted global attention in …

Comparative study of the mechanism of natural compounds with similar structures using docking and transcriptome data for improving in silico herbal medicine …

M Park, SJ Baek, SM Park, JM Yi… - Briefings in …, 2023 - academic.oup.com
Natural products have successfully treated several diseases using a multi-component, multi-
target mechanism. However, a precise mechanism of action (MOA) has not been identified …

[HTML][HTML] YaTCM: yet another traditional Chinese medicine database for drug discovery

B Li, C Ma, X Zhao, Z Hu, T Du, X Xu, Z Wang… - Computational and …, 2018 - Elsevier
Abstract Traditional Chinese Medicine (TCM) has a long history of widespread clinical
applications, especially in East Asia, and is becoming frequently used in Western countries …

Metabolomics coupled with similarity analysis advances the elucidation of the cold/hot properties of traditional Chinese medicines

JIA Yan, ZZ Zhang, WEI Yu-Hai, Q Xue-Mei… - Chinese journal of …, 2017 - Elsevier
It recently becomes an important and urgent mission for modern scientific research to
identify and explain the theory of traditional Chinese medicine (TCM), which has been …

A systems biology approach to understanding the mechanisms of action of Chinese herbs for treatment of cardiovascular disease

B Li, X Xu, X Wang, H Yu, X Li, W Tao, Y Wang… - International journal of …, 2012 - mdpi.com
Traditional Chinese Medicine (TCM) involves a broad range of empirical testing and
refinement and plays an important role in the health maintenance for people all over the …