Traditionally, the field of genomics has been studied from a biochemical perspective.
Besides chemical influences, cells are subject to a variety of mechanical signals from their …

Transcription initiation is a major control point for the precise regulation of gene expression.
Our knowledge of this process has been mainly derived from protein-centric studies wherein …

The compaction of linear DNA into micrometer-sized nuclear boundaries involves the
establishment of specific three-dimensional (3D) DNA structures complexed with histone …

It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

Mechanical forces drive and modulate a wide variety of processes in eukaryotic cells
including those occurring in the nucleus. Relevantly, forces are fundamental during …

DNA is traditionally seen as a linear sequence of instructions for cellular functions that are
expressed through biochemical processes. Cellular DNA, however, is also organized as a …

All living organisms experience force (Figure 1). These forces exist at the nanoscale level
through to the tissue level and range from piconewtons upward to several orders of …

Immune cells react to a wide range of environments, both chemical and physical. While the
former has been extensively studied, there is growing evidence that physical and in …

Living cells can sense mechanical forces and convert them into biological responses.
Similarly, biological and biochemical signals are known to influence the abilities of cells to …