Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

MS Uddin, A Al Mamun, M Jakaria… - Science of the Total …, 2020 - Elsevier
Neurological disorders represent a great challenge and are the leading cause of death and
disability globally. Although numerous complicated mechanisms are involved in the …

Effects of sulforaphane in the central nervous system

C Huang, J Wu, D Chen, J Jin, Y Wu, Z Chen - European journal of …, 2019 - Elsevier
Sulforaphane (SFN) is an active component extracted from vegetables like cauliflower and
broccoli. Activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling is a …

Pre-clinical neuroprotective evidences and plausible mechanisms of Sulforaphane in Alzheimer's disease

J Kim - International journal of molecular sciences, 2021 - mdpi.com
Sulforaphane, a potent dietary bioactive agent obtainable from cruciferous vegetables, has
been extensively studied for its effects in disease prevention and therapy. Sulforaphane …

The neuroprotective mechanisms and effects of sulforaphane

EA Klomparens, Y Ding - Brain Circulation, 2019 - journals.lww.com
Sulforaphane (SFN) is a phytochemical found in cruciferous vegetables. It has been shown
to have many protective effects against many diseases, including multiple types of cancer …

Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2 and autophagy pathways

Q Zhou, B Chen, X Wang, L Wu, Y Yang, X Cheng… - Scientific reports, 2016 - nature.com
Sulforaphane, a naturally occurring compound found in cruciferous vegetables, has been
shown to be neuroprotective in several neurological disorders. In this study, we sought to …

Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice

B Li, W Cui, J Liu, R Li, Q Liu, XH Xie, XL Ge… - Experimental …, 2013 - Elsevier
Sulforaphane (SFN) is an organosulfur compound present in vegetables and has potent anti-
oxidant and anti-inflammatory activities. This study was aimed at investigating the effect of …

Targeting the Nrf2 signaling pathway using phytochemical ingredients: A novel therapeutic road map to combat neurodegenerative diseases

X Bai, Z Bian, M Zhang - Phytomedicine, 2023 - Elsevier
Background Nuclear factor erythroid 2-related factor 2 (Nrf2) is a classical nuclear
transcription factor that regulates the system's anti-oxidative stress response. The activation …

[PDF][PDF] Current potential health benefits of sulforaphane

JK Kim, SU Park - 2016 - 129.217.131.68
Sulforaphane [SFN: 1-isothiocyanato-4-(methylsulfinyl) butane] belongs to the
isothiocyanate class of phytochemicals. Glucoraphanin, a glucosinolate precursor of SFN, is …

The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis

EJ Calabrese, WJ Kozumbo - Pharmacological research, 2021 - Elsevier
In numerous experimental models, sulforaphane (SFN) is shown herein to induce hormetic
dose responses that are not only common but display endpoints of biomedical and clinical …

Sulforaphane-role in aging and neurodegeneration

R Santín-Márquez, A Alarcón-Aguilar… - Geroscience, 2019 - Springer
In the last several years, numerous molecules derived from plants and vegetables have
been tested for their antioxidant, anti-inflammatory, and anti-aging properties. One of them is …