Myths and methodologies: Assessment of dynamic cerebral autoregulation by the mean flow index

MH Olsen, CG Riberholt, RMG Berg… - Experimental …, 2024 - Wiley Online Library
The mean flow index—usually referred to as Mx—has been used for assessing dynamic
cerebral autoregulation (dCA) for almost 30 years. However, concerns have arisen …

Reliability and validity of the mean flow index (Mx) for assessing cerebral autoregulation in humans: a systematic review of the methodology

MH Olsen, CG Riberholt, J Mehlsen… - Journal of Cerebral …, 2022 - journals.sagepub.com
Cerebral autoregulation is a complex mechanism that serves to keep cerebral blood flow
relatively constant within a wide range of cerebral perfusion pressures. The mean flow index …

Reliability of the mean flow index (Mx) for assessing cerebral autoregulation in healthy volunteers

MH Olsen, CG Riberholt, RR Plovsing… - Physiological …, 2021 - Wiley Online Library
Abstract Background Mean flow index (Mxa) for evaluating dynamic cerebral autoregulation
is derived using varying approaches for calculation, which may explain that the reliability …

Diagnostic and prognostic performance of Mxa and transfer function analysis-based dynamic cerebral autoregulation metrics

MH Olsen, C Riberholt, RR Plovsing… - Journal of Cerebral …, 2022 - journals.sagepub.com
Dynamic cerebral autoregulation is often assessed by continuously recorded arterial blood
pressure (ABP) and transcranial Doppler-derived mean cerebral blood flow velocity followed …

Dynamic cerebral autoregulation: different signal processing methods without influence on results and reproducibility

ED Gommer, E Shijaku, WH Mess… - Medical & biological …, 2010 - Springer
Cerebral autoregulation controls cerebral blood flow under changing cerebral perfusion
pressure. Standards for measurement and analysis of dynamic cerebral autoregulation …

Reproducibility of dynamic cerebral autoregulation parameters: a multi-centre, multi-method study

ML Sanders, JAHR Claassen, M Aries… - Physiological …, 2018 - iopscience.iop.org
Objective: Different methods to calculate dynamic cerebral autoregulation (dCA) parameters
are available. However, most of these methods demonstrate poor reproducibility that limit …

Transfer function analysis of dynamic cerebral autoregulation: a CARNet white paper 2022 update

RB Panerai, P Brassard, JS Burma… - Journal of Cerebral …, 2023 - journals.sagepub.com
Cerebral autoregulation (CA) refers to the control of cerebral tissue blood flow (CBF) in
response to changes in perfusion pressure. Due to the challenges of measuring intracranial …

Dynamic cerebral autoregulation reproducibility is affected by physiological variability

ML Sanders, JWJ Elting, RB Panerai, M Aries… - Frontiers in …, 2019 - frontiersin.org
Parameters describing dynamic cerebral autoregulation (DCA) have limited reproducibility.
In an international, multi-center study, we evaluated the influence of multiple analytical …

Transfer function analysis of dynamic cerebral autoregulation: a white paper from the International Cerebral Autoregulation Research Network

JAHR Claassen… - Journal of Cerebral …, 2016 - journals.sagepub.com
Cerebral autoregulation is the intrinsic ability of the brain to maintain adequate cerebral
perfusion in the presence of blood pressure changes. A large number of methods to assess …

Reliability of the transcranial Doppler ultrasound-derived mean flow index for assessing dynamic cerebral autoregulation in healthy volunteers

CG Riberholt, MH Olsen, LT Skovgaard… - Medical Engineering & …, 2021 - Elsevier
The transcranial Doppler ultrasound-derived mean flow index (Mxa) is widely used for
assessing dynamic cerebral autoregulation (dCA) in different clinical populations. This study …