Several viral vector-based gene therapy drugs have now received marketing approval. A
much larger number of additional viral vectors are in various stages of clinical trials for the …

Viral vectors are potent gene delivery platforms used for the treatment of genetic and
acquired diseases. However, just as viruses have evolved to infect cells efficiently, the …

Circumventing the immune response to the vector is a major challenge with all vector types.
Viral vectors are the most likely to induce an immune response, especially those, like …

Adenoviral (Ad) vectors can efficiently transduce a broad range of cell types and have been
used extensively in preclinical and clinical studies for gene delivery applications. The …

Viral vectors have provided effective methods for in vivo gene delivery for therapeutic
purposes. The ability of viruses to infect a wide variety of cell types in vivo has been …

E1, E3-deleted, replication-deficient recombinant adenoviruses are widely studied as
vectors for their capacity to transfer therapeutic genes in vivo. They can infect a wide variety …

Recombinant viral vectors such as adenovirus and adenovirus-associated virus have been
used widely as vehicles for gene therapy applications because of the high efficiency with …

Gene therapy is a clinical strategy that has the potential to treat an array of genetic and
nongenetic diseases. Vectors for gene transfer are the essential tools of gene therapy. For …

Gene therapy is an interesting approach for the correction of defective genes, the treatment
of cancer and the introduction of immunomodulatory genes. Various techniques for gene …

Human adenoviruses have been adopted as attractive vectors for in vivo gene therapy since
they have a well-characterized genomic organization, can be grown to high titres and …