Current antiretroviral therapy for HIV-1 infection does not represent a cure for infection as
viral rebound inevitably occurs following discontinuation of treatment. The “block and lock” …

Introduction: A number of cyclin-dependent kinases (CDKs) mediate key steps in the HIV-1
replication cycle and therefore have potential to serve as therapeutic targets for HIV-1 …

Cyclin-dependent kinases (cdk's) have recently been suggested to regulate human
immunodeficiency virus type 1 (HIV-1) transcription. Previously, we have shown that …

Hijacking of the host cell's signal transduction machinery has been increasingly regarded as
an important strategy for facilitating virus propagation. The positive-transcription elongation …

Latent HIV-1 provirus represents the barrier toward a cure for infection and is dependent
upon the host RNA Polymerase (Pol) II machinery for reemergence. Here, we find that …

Human immunodeficiency virus type 1 (HIV-1) can infect quiescent cells, however, viral
production is restricted to actively proliferating cells. Recent evidence has indicated that HIV …

There are currently 40 million individuals in the world infected with human
immunodeficiency virus (HIV). The introduction of highly active antiretroviral therapy …

While the roles in HIV transcription of many cyclin-dependent kinases (CDKs) have been
well defined, little is known about the impact of mediator kinases (MDKs), CDK8 and CDK19 …

While combination antiretroviral therapy (cART) durably suppresses HIV replication, virus
persists in CD4+ T-cells that harbor latent but spontaneously inducible and replication …

Potent anti-retroviral therapy has transformed HIV-1 infection into a chronic manageable
disease; however, drug resistance remains a common problem that limits the effectiveness …