The aim of the present study was to investigate the course of cerebral blood flow (CBF) and
metabolism in traumatic brain injury (TBI) patients and to specifically characterize the …

Objective: To investigate and compare the respective dynamics of cerebral blood flow (CBF)
and metabolism in response to changes in neurological condition and intracranial pressure …

Because it is the product of glycolysis and main substrate for mitochondrial respiration,
lactate is the central metabolic intermediate in cerebral energy substrate delivery. Our recent …

The purpose of this study was to determine if the relationship between abnormalities in
glucose, lactate, and oxygen metabolism were predictive of neurologic outcome after …

Object Ischemic lesions are highly prevalent in patients with traumatic brain injuries (TBIs)
and are the single most important cause of secondary brain damage. The prevention and …

Severe head injury is frequently associated with focal or global disturbances of cerebral
blood flow and metabolism. Routine monitoring of intracranial pressure (ICP) and cerebral …

Growing evidence suggests that endogenous lactate is an important substrate for neurons.
This study aimed to examine cerebral lactate metabolism and its relationship with brain …

Purpose High arterial lactate is associated with disturbed systemic physiology. Lactate can
also be used as alternative cerebral fuel and it is involved in regulating cerebral blood flow …

Background: Neuromonitoring with microdialysis has the potential for early detection of
metabolic derangements associated with TBI. Methods: 1,260 microdialysis samples from 12 …

We evaluated the hypothesis that lactate shuttling helps support the nutritive needs of
injured brains. To that end, we utilized dual isotope tracer [6, 6-2H2] glucose, that is, D2 …