[HTML][HTML] Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
TM Ross, AE Oran, BR Cullen - Current Biology, 1999 - cell.com
Background: The human immunodeficiency virus type 1 (HIV-1) Nef protein is required for
efficient virus replication in vivo and displays a number of distinct and apparently unrelated …
efficient virus replication in vivo and displays a number of distinct and apparently unrelated …
Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells
M Tobiume, JE Lineberger, CA Lundquist… - Journal of …, 2003 - Am Soc Microbiol
The human immunodeficiency virus type 1 (HIV-1) accessory protein Nef stimulates viral
infectivity by an unknown mechanism. Recent studies have suggested that Nef may act by …
infectivity by an unknown mechanism. Recent studies have suggested that Nef may act by …
[HTML][HTML] Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef-and Vpu-inhibitable manner
Abstract Background: Human immunodeficiency virus-1 (HIV-1) infection decreases the cell-
surface expression of its cellular receptor, CD4, through the combined actions of Nef, Env …
surface expression of its cellular receptor, CD4, through the combined actions of Nef, Env …
Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef
MA Goldsmith, MT Warmerdam, RE Atchison… - Journal of …, 1995 - Am Soc Microbiol
Recent evidence indicates that the nef gene of human immunodeficiency virus type 1
augments rather than inhibits viral replication in both cell culture and in vivo models. In …
augments rather than inhibits viral replication in both cell culture and in vivo models. In …
[HTML][HTML] Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication
ER Argañaraz, M Schindler, F Kirchhoff… - Journal of Biological …, 2003 - ASBMB
Three viral proteins participate in the down-modulation of CD4 in human immunodeficiency
virus type 1 (HIV-1)-infected cells. The underlying mechanisms have been extensively …
virus type 1 (HIV-1)-infected cells. The underlying mechanisms have been extensively …
Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral …
MD Miller, MT Warmerdam, KA Page… - Journal of …, 1995 - Am Soc Microbiol
The nef gene product of human immunodeficiency virus type 1 (HIV-1) promotes more-rapid
kinetics of viral replication in primary peripheral blood mononuclear cells. We have …
kinetics of viral replication in primary peripheral blood mononuclear cells. We have …
Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes
CA Lundquist, M Tobiume, J Zhou, D Unutmaz… - Journal of …, 2002 - Am Soc Microbiol
The accessory protein Nef plays a crucial role in primate lentivirus pathogenesis. Nef
enhances human immunodeficiency virus type 1 (HIV-1) infectivity in culture and stimulates …
enhances human immunodeficiency virus type 1 (HIV-1) infectivity in culture and stimulates …
[HTML][HTML] Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex
S Cho, KS Knox, LM Kohli, JJ He, MA Exley, SB Wilson… - Virology, 2005 - Elsevier
The HIV-1 Nef protein causes a decrease in major histocompatibility complex (MHC) class I
and CD4 molecule expression on the cell surface. To determine if Nef can affect …
and CD4 molecule expression on the cell surface. To determine if Nef can affect …
The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef
SJ Anderson, M Lenburg, NR Landau… - Journal of virology, 1994 - Am Soc Microbiol
Human immunodeficiency virus type 1 Nef down-regulates surface expression of murine
and human CD4 but not human CD8. We recently reported that the cytoplasmic domain of …
and human CD4 but not human CD8. We recently reported that the cytoplasmic domain of …
[HTML][HTML] Cell surface CD4 inhibits HIV-1 particle release by interfering with Vpu activity
S Bour, C Perrin, K Strebel - Journal of Biological Chemistry, 1999 - ASBMB
One of the hallmarks of human immunodeficiency virus type I (HIV-1) infection is the rapid
removal of the viral receptor CD4 from the cell surface. This remarkably efficient receptor …
removal of the viral receptor CD4 from the cell surface. This remarkably efficient receptor …
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