Bacterial genomes are partitioned into kilobases long domains that are topologically
independent from each other, meaning that change of DNA superhelicity in one domain …

Bacterial genomes have been shown to be partitioned into several-kilobase-long
chromosomal domains that are topologically independent from each other, meaning that …

The chromosome of archetypal bacteria E. coli is known for a complex topology with a 4.6×
106 base pairs (bp) long sequence of nucleotides packed within a micrometer-sized cellular …

The torque generated by RNA polymerase as it tracks along double-stranded DNA can
potentially induce long-range structural deformations integral to mechanisms of biological …

DNA torsion dynamics is essential in the transcription process; simple models for it have
been proposed by several authors, in particular Yakushevich (Y model). These are strongly …

The central focus of this thesis is the study of the physical properties of DNA, the carrier of all
genetic information. These properties set the ground rules for the organization of the …

DNA is a long polymeric substrate that provides specific binding sites for many proteins in
cell nucleus. Both diffusion and directed translocation play an essential role for protein-DNA …

Topological constraints, such as those associated with DNA supercoiling, play an integral
role in genomic regulation and organization in living systems. However, physical …

The topology of DNA is a key element in the regulation of the molecule's biological function.
By micromanipulating single DNA molecules, we investigate the molecule's response to …

Virtually all processes of the genome biology affect or are affected by the torsional state of
DNA. Torsional energy associated with an altered twist facilitates or hinders the melting of …