Development of nonsurfactant cyclodextrin nanoparticles loaded with anticancer drug paclitaxel
E Bilensoy, O Gürkaynak, M Ertan, M Şen… - Journal of …, 2008 - Elsevier
In the current formulation of clinical use paclitaxel (PCX) is associated with solubilizers that
may produce severe side effects. In this study, PCX was complexed to an amphiphilic …
may produce severe side effects. In this study, PCX was complexed to an amphiphilic …
Safety and efficacy of amphiphilic ß-cyclodextrin nanoparticles for paclitaxel delivery
E Bilensoy, O Gürkaynak, AL Doğan… - International journal of …, 2008 - Elsevier
Paclitaxel is a potent anticancer agent with limited bioavailability due to side-effects
associated with solubilizer used in its commercial formulation and the tendency of the drug …
associated with solubilizer used in its commercial formulation and the tendency of the drug …
[HTML][HTML] Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery
Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum
of cancers. To overcome its bioavailability problems arising from very poor aqueous …
of cancers. To overcome its bioavailability problems arising from very poor aqueous …
Therapeutic efficacy and biodistribution of paclitaxel-bound amphiphilic cyclodextrin nanoparticles: analyses in 3D tumor culture and tumor-bearing animals in vivo
The uniqueness of paclitaxel's antimitotic action mechanism has fueled research toward its
application in more effective and safer cancer treatments. However, the low water solubility …
application in more effective and safer cancer treatments. However, the low water solubility …
Increased oral bioavailability of paclitaxel by its encapsulation through complex formation with cyclodextrins in poly (anhydride) nanoparticles
M Agüeros, V Zabaleta, S Espuelas… - Journal of Controlled …, 2010 - Elsevier
The aim of this work was to study the oral bioavailability in rats of paclitaxel (PTX) when
encapsulated as a complex with cyclodextrins in poly (anhydride) nanoparticles (NP). For …
encapsulated as a complex with cyclodextrins in poly (anhydride) nanoparticles (NP). For …
The intracellular effects of non-ionic amphiphilic cyclodextrin nanoparticles in the delivery of anticancer drugs
The aim of this study was to develop nanoparticles made of the amphiphilic cyclodextrin
heptakis (2-O-oligo (ethyleneoxide)-6-hexadecylthio-)-β-CD (SC16OH) entrapping …
heptakis (2-O-oligo (ethyleneoxide)-6-hexadecylthio-)-β-CD (SC16OH) entrapping …
The preparation, characterization, and pharmacokinetic studies of chitosan nanoparticles loaded with paclitaxel/dimethyl-β-cyclodextrin inclusion complexes
YJ Ye, Y Wang, KY Lou, YZ Chen… - International journal of …, 2015 - Taylor & Francis
A novel biocompatible and biodegradable drug-delivery nanoparticle (NP) has been
developed to minimize the severe side effects of the poorly water-soluble anticancer drug …
developed to minimize the severe side effects of the poorly water-soluble anticancer drug …
Development of implantable hydroxypropyl-β-cyclodextrin coated polycaprolactone nanoparticles for the controlled delivery of docetaxel to solid tumors
C Varan, E Bilensoy - Journal of Inclusion Phenomena and Macrocyclic …, 2014 - Springer
Abstract Treatment of cancer is one of the most challenging problems and conventional
therapies are inadequate for targeted, effective and safe therapy. Development of …
therapies are inadequate for targeted, effective and safe therapy. Development of …
[HTML][HTML] Formulation development, stability and anticancer efficacy of core-shell cyclodextrin nanocapsules for oral chemotherapy with camptothecin
H Ünal, N Öztürk, E Bilensoy - Beilstein journal of organic …, 2015 - beilstein-journals.org
Background: The aim of this study was to design and evaluate hybrid cyclodextrin (CD)
nanocapsules intended for the oral delivery of the anticancer agent camptothecin (CPT) in …
nanocapsules intended for the oral delivery of the anticancer agent camptothecin (CPT) in …
Cyclodextrin-derived pH-responsive nanoparticles for delivery of paclitaxel
H He, S Chen, J Zhou, Y Dou, L Song, L Che, X Zhou… - Biomaterials, 2013 - Elsevier
Engineering of pH-responsive nanoplatforms can be facilely achieved from acetalated α-
cyclodextrin materials. The hydrolysis period of nanoparticles can be precisely tailored by …
cyclodextrin materials. The hydrolysis period of nanoparticles can be precisely tailored by …
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