In the current formulation of clinical use paclitaxel (PCX) is associated with solubilizers that
may produce severe side effects. In this study, PCX was complexed to an amphiphilic …

Paclitaxel is a potent anticancer agent with limited bioavailability due to side-effects
associated with solubilizer used in its commercial formulation and the tendency of the drug …

Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum
of cancers. To overcome its bioavailability problems arising from very poor aqueous …

The uniqueness of paclitaxel's antimitotic action mechanism has fueled research toward its
application in more effective and safer cancer treatments. However, the low water solubility …

The aim of this work was to study the oral bioavailability in rats of paclitaxel (PTX) when
encapsulated as a complex with cyclodextrins in poly (anhydride) nanoparticles (NP). For …

The aim of this study was to develop nanoparticles made of the amphiphilic cyclodextrin
heptakis (2-O-oligo (ethyleneoxide)-6-hexadecylthio-)-β-CD (SC16OH) entrapping …

A novel biocompatible and biodegradable drug-delivery nanoparticle (NP) has been
developed to minimize the severe side effects of the poorly water-soluble anticancer drug …

Abstract Treatment of cancer is one of the most challenging problems and conventional
therapies are inadequate for targeted, effective and safe therapy. Development of …

Background: The aim of this study was to design and evaluate hybrid cyclodextrin (CD)
nanocapsules intended for the oral delivery of the anticancer agent camptothecin (CPT) in …

Engineering of pH-responsive nanoplatforms can be facilely achieved from acetalated α-
cyclodextrin materials. The hydrolysis period of nanoparticles can be precisely tailored by …