FLT3 mutations, either internal tandem duplications (ITDs) or aspartate residue 835 (D835)
point mutations, are present in approximately one third of patients with acute myeloid …

Analysis of internal tandem duplications of FLT3 (FLT3/ITD) was performed on bone marrow
samples obtained at diagnosis and relapse from 108 adult patients with de novo acute …

The FLT3 gene is mutated by an internal tandem duplication (ITD) in 20–25% of adults with
acute myeloid leukemia (AML). We studied 82 adults< 60 years of age with primary AML and …

Abstract FLT3 length mutation (FLT3-LM) is a molecular marker potentially useful for the
characterization of acute myeloid leukemia (AML). To evaluate the distribution of FLT3-LM …

Internal tandem duplications in FLT3 are the most common mutation in acute myeloid
leukaemia (AML), with agarose gel electrophoresis of polymerase chain reaction products …

To assess the prognostic relevance of activating mutations of the FLT3 gene in
homogeneously treated adults 16 to 60 years of age with acute myeloid leukemia (AML) and …

Genomic DNA from 106 cases of adult de novo acute myeloid leukaemia (AML) was
screened by polymerase chain reaction (PCR) and gel electrophoresis for FLT3 internal …

Constitutive activation of the FLT3 receptor tyrosine kinase, either by internal tandem
duplication (ITD) of the juxtamembrane region or by point mutations in the second tyrosine …

BACKGROUND AND OBJECTIVES: Cytogenetics is the most important prognostic factor in
acute myeloid leukemia (AML). However, a high proportion of patients show normal or …

In acute myeloid leukemia (AML), further prognostic determinants are required in addition to
cytogenetics to predict patients at increased risk of relapse. Recent studies have indicated …