The Effects of Alpha‐Linolenic Acid on the Secretory Activity of Astrocytes and β Amyloid‐Associated Neurodegeneration in Differentiated SH‐SY5Y Cells: Alpha‐Linolenic Acid …
A Litwiniuk, A Domańska… - Oxidative medicine …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is the most common neurodegenerative disorder. Amyloid β‐(Aβ‐)
induced mitochondrial dysfunction may be a primary process triggering all the cascades of …
induced mitochondrial dysfunction may be a primary process triggering all the cascades of …
Alpha-linolenic acid regulates amyloid precursor protein processing by mitogen-activated protein kinase pathway and neuronal apoptosis in amyloid beta-induced SH …
AY Lee, MH Lee, S Lee, EJ Cho - Applied Biological Chemistry, 2018 - Springer
Abstract Alpha-linolenic acid (ALA), which is an omega-3 fatty acid from plant oils, has been
reported to have beneficial effects on human brain health. However, the protective effect of …
reported to have beneficial effects on human brain health. However, the protective effect of …
Autophagy activation alleviates amyloid-β-induced oxidative stress, apoptosis and neurotoxicity in human neuroblastoma SH-SY5Y cells
Autophagy is an evolutionary conserved catabolic process that ensures continuous removal
of damaged cell organelles and long-lived protein aggregates to maintain cellular …
of damaged cell organelles and long-lived protein aggregates to maintain cellular …
[HTML][HTML] Neuroprotective Effect of Membrane-Free Stem Cell Extract against Amyloid Beta 25–35-Induced Neurotoxicity in SH-SY5Y Cells
HS Park, QQ Pang, YS Kim, JH Kim, EJ Cho - Applied Sciences, 2021 - mdpi.com
Amyloid beta (Aβ) produced by the amyloidogenic pathway induces neurotoxicity, and its
accumulation is a well-known cause of Alzheimer's disease (AD). In this study, the protective …
accumulation is a well-known cause of Alzheimer's disease (AD). In this study, the protective …
Asiatic acid protects differentiated PC12 cells from Aβ25–35-induced apoptosis and tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β signaling
W Cheng, W Chen, P Wang, J Chu - Life Sciences, 2018 - Elsevier
Amyloid β (Aβ) peptide can cause neurotoxicity in Alzheimer's disease (AD). The main
purpose of the present study is to investigate the protective role of asiatic acid (AA) against …
purpose of the present study is to investigate the protective role of asiatic acid (AA) against …
Neuroprotective effect of alpha-linolenic acid against Aβ-mediated inflammatory responses in C6 glial cell
AY Lee, MH Lee, S Lee, EJ Cho - Journal of agricultural and food …, 2018 - ACS Publications
Therapeutic approaches for neurodegeneration, such as Alzheimer's disease (AD), have
been widely studied. One of the critical hallmarks of AD is accumulation of amyloid beta …
been widely studied. One of the critical hallmarks of AD is accumulation of amyloid beta …
Hydroxytyrosol restores proper insulin signaling in an astrocytic model of Alzheimer's disease
MC Crespo, J Tomé‐Carneiro, C Pintado… - Biofactors, 2017 - Wiley Online Library
Recent epidemiological evidence demonstrated that diabetes is a risk factor for AD onset
and development. Indeed, meta‐analyses of longitudinal epidemiologic studies show that …
and development. Indeed, meta‐analyses of longitudinal epidemiologic studies show that …
Ginsenoside Rg1 prevents SK-N-SH neuroblastoma cell apoptosis induced by supernatant from Aβ1–40-stimulated THP-1 monocytes
W Li, Y Chu, L Zhang, L Yin, L Li - Brain Research Bulletin, 2012 - Elsevier
Excessive accumulation of amyloid-β (Aβ) has been proposed as a pivotal event in
Alzheimer's disease (AD) pathogenesis. Possible mechanisms underlying Aβ-induced …
Alzheimer's disease (AD) pathogenesis. Possible mechanisms underlying Aβ-induced …
Inhibition of glycogen synthase kinase‐3β by Angelica sinensis extract decreases β‐amyloid‐induced neurotoxicity and tau phosphorylation in cultured cortical …
Z Zhang, R Zhao, J Qi, S Wen, Y Tang… - Journal of …, 2011 - Wiley Online Library
Increasing evidence has shown that β‐amyloid (Aβ) induces hyperphosphorylation of tau
and contributes to Aβ toxicity. Recently, tau hyperphosphorylation by glycogen synthase …
and contributes to Aβ toxicity. Recently, tau hyperphosphorylation by glycogen synthase …
The neuroprotective effects of alpha‐lipoic acid on an experimental model of Alzheimer's disease in PC12 cells
X Pei, F Hu, F Luo, X Huang, X Li… - Journal of Applied …, 2022 - Wiley Online Library
With the growth of the aging population, the prevalence of Alzheimer's disease (AD) has
increased and influenced the work and daily life of AD patients, imposing a heavy burden on …
increased and influenced the work and daily life of AD patients, imposing a heavy burden on …
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