Regulation of macrophage development and function in peripheral tissues

Y Lavin, A Mortha, A Rahman, M Merad - Nature Reviews Immunology, 2015 - nature.com
Macrophages are immune cells of haematopoietic origin that provide crucial innate immune
defence and have tissue-specific functions in the regulation and maintenance of organ …

Macrophages: development and tissue specialization

C Varol, A Mildner, S Jung - Annual review of immunology, 2015 - annualreviews.org
Macrophages are myeloid immune cells that are strategically positioned throughout the
body tissues, where they ingest and degrade dead cells, debris, and foreign material and …

[HTML][HTML] Tissue-specific macrophages: how they develop and choreograph tissue biology

E Mass, F Nimmerjahn, K Kierdorf… - Nature Reviews …, 2023 - nature.com
Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Origin, development, and homeostasis of tissue‐resident macrophages

M Haldar, KM Murphy - Immunological reviews, 2014 - Wiley Online Library
Macrophages are versatile cells of the hematopoietic system that display remarkable
functional diversity encompassing innate immune responses, tissue development, and …

Origins and diversity of macrophages in health and disease

G Sreejit, AJ Fleetwood, AJ Murphy… - Clinical & …, 2020 - Wiley Online Library
Macrophages are the first immune cells in the developing embryo and have a central role in
organ development, homeostasis, immunity and repair. Over the last century, our …

Developmental control of macrophage function

J Bonnardel, M Guilliams - Current opinion in immunology, 2018 - Elsevier
Highlights•We review the potential impact of cellular origin on the function of
macrophages.•We discuss the recent evidence for macrophages plasticity.•We also highlight …

Delineating the origins, developmental programs and homeostatic functions of tissue-resident macrophages

E Mass - International Immunology, 2018 - academic.oup.com
A literature covering 150 years of research indicates that macrophages are a diverse family
of professional phagocytes that continuously explore their environment, recognize and …

Transcriptional control of monocyte and macrophage development

D Kurotaki, H Sasaki, T Tamura - International immunology, 2017 - academic.oup.com
Monocytes and macrophages play critical roles in immune responses, tissue homeostasis
and disease progression. There are a number of functionally and phenotypically distinct …

Monocytes and macrophages: developmental pathways and tissue homeostasis

F Ginhoux, S Jung - Nature Reviews Immunology, 2014 - nature.com
Monocytes and macrophages have crucial and distinct roles in tissue homeostasis and
immunity, but they also contribute to a broad spectrum of pathologies and are thus attractive …

Tissue biology perspective on macrophages

Y Okabe, R Medzhitov - Nature immunology, 2016 - nature.com
Macrophages are essential components of mammalian tissues. Although historically known
mainly for their function in host defense and the clearance of apoptotic cells, macrophages …