[HTML][HTML] IL-21 induces an imbalance of Th17/Treg cells in moderate-to-severe plaque psoriasis patients
Background: Psoriasis is a chronic immune-mediated inflammatory skin disease, with over-
activated interleukin (IL)-17-producing CD4+ T cells (Th17) and repressed regulatory T …
activated interleukin (IL)-17-producing CD4+ T cells (Th17) and repressed regulatory T …
[HTML][HTML] Interleukin-21 is associated with the severity of psoriasis vulgaris through promoting CD4+ T cells to differentiate into Th17 cells
Y Wang, LL Wang, HY Yang, FF Wang… - American Journal of …, 2016 - ncbi.nlm.nih.gov
Abstract Interleukin-21 (IL-21) and T helper 17 (Th17) cells are known to be involved in the
pathogenesis of psoriasis, but little is known about their relationship in psoriasis. Herein, we …
pathogenesis of psoriasis, but little is known about their relationship in psoriasis. Herein, we …
[HTML][HTML] Interleukin-17A drives IL-19 and IL-24 expression in skin stromal cells regulating keratinocyte proliferation
X Xu, E Prens, E Florencia, P Leenen, L Boon… - Frontiers in …, 2021 - frontiersin.org
IL-17A has been shown to be up-regulated in psoriasis lesions and is central to psoriasis
pathogenesis. IL-19, along with other IL-20 subfamily cytokines such as IL-20 and IL-24, is …
pathogenesis. IL-19, along with other IL-20 subfamily cytokines such as IL-20 and IL-24, is …
[HTML][HTML] IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation
HL Ma, S Liang, J Li, L Napierata… - The Journal of …, 2008 - Am Soc Clin Investig
Psoriasis is a chronic skin disease resulting from the dysregulated interplay between
keratinocytes and infiltrating immune cells. We report on a psoriasis-like disease model …
keratinocytes and infiltrating immune cells. We report on a psoriasis-like disease model …
[HTML][HTML] IL-19 is a component of the pathogenetic IL-23/IL-17 cascade in psoriasis
E Witte, G Kokolakis, K Witte, S Philipp… - Journal of Investigative …, 2014 - Elsevier
Psoriasis is a common chronic inflammatory disease with characteristic skin alterations and
functions as a model of immune-mediated disorders. Cytokines have a key role in psoriasis …
functions as a model of immune-mediated disorders. Cytokines have a key role in psoriasis …
Increased Th17 cells are accompanied by FoxP3+ Treg cell accumulation and correlated with psoriasis disease severity
L Zhang, XQ Yang, J Cheng, RS Hui, TW Gao - Clinical immunology, 2010 - Elsevier
Both T-helper 17 cells (Th17) and CD4+ CD25+ regulatory T cells (Treg) play important
roles in the pathogenesis of psoriasis. However, the relationship between Th17 and Treg …
roles in the pathogenesis of psoriasis. However, the relationship between Th17 and Treg …
Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines
E Fitch, E Harper, I Skorcheva, SE Kurtz… - Current rheumatology …, 2007 - Springer
Abstract T helper (Th) 17 cells, a novel T-cell subset, have been implicated in the
pathogenesis of psoriasis and other autoimmune inflammatory diseases. Interleukin (IL)-23 …
pathogenesis of psoriasis and other autoimmune inflammatory diseases. Interleukin (IL)-23 …
IL-21 promotes skin recruitment of CD4+ cells and drives IFN-γ–dependent epidermal hyperplasia
M Sarra, R Caruso, ML Cupi, I Monteleone… - The Journal of …, 2011 - journals.aai.org
Psoriasis is a chronic inflammatory disorder of the skin characterized by epidermal
hyperplasia and infiltration of leukocytes into the dermis and epidermis. T cell-derived …
hyperplasia and infiltration of leukocytes into the dermis and epidermis. T cell-derived …
[HTML][HTML] Interleukin-23 and interleukin-17: importance in pathogenesis and therapy of psoriasis
P Mudigonda, T Mudigonda, AN Feneran… - Dermatology online …, 2012 - escholarship.org
Emerging data in mice and humans reveals a critical contribution of Th17-associated
cytokines, particularly interleukin-(IL)-23 and IL-17, in the pathogenesis of psoriasis. The IL …
cytokines, particularly interleukin-(IL)-23 and IL-17, in the pathogenesis of psoriasis. The IL …
IL-29 Is Produced by TH17 Cells and Mediates the Cutaneous Antiviral Competence in Psoriasis
K Wolk, K Witte, E Witte, M Raftery… - Science translational …, 2013 - science.org
Psoriasis and atopic dermatitis (AD) are the most common chronic inflammatory skin
diseases. Although both patient groups show strongly impaired skin barrier function, only AD …
diseases. Although both patient groups show strongly impaired skin barrier function, only AD …