Ploidy abnormalities are a hallmark of cancer, but their impact on the evolution and
outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the …

Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the
entire chromosome complement. However, despite its prevalence and prognostic relevance …

Whole-genome doubling (WGD) is common in human cancers, occurring early in
tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour …

Aneuploidy is a hallmark of cancer with tissue-specific prevalence patterns that suggest it
plays a driving role in cancer initiation and progression. However, the contribution of …

The contribution of whole-genome doubling to chromosomal instability (CIN) and tumor
evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable …

An unstable genome is a hallmark of many cancers. It is unclear, however, whether some
mutagenic features driving somatic alterations in cancer are encoded in the genome …

The impact of somatic structural variants (SVs) on gene expression in cancer is largely
unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes …

Up to 80% of human cancers, in particular solid tumors, contain cells with abnormal
chromosomal numbers, or aneuploidy, which is often linked with marked chromosomal …

Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …

The overwhelming majority of proliferating somatic human cells are diploid, and this
genomic state is typically maintained across successive cell divisions. However, failures in …