Genome doubling shapes the evolution and prognosis of advanced cancers
Ploidy abnormalities are a hallmark of cancer, but their impact on the evolution and
outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the …
outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the …
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution
Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the
entire chromosome complement. However, despite its prevalence and prognostic relevance …
entire chromosome complement. However, despite its prevalence and prognostic relevance …
Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
RJ Quinton, A DiDomizio, MA Vittoria, K Kotýnková… - Nature, 2021 - nature.com
Whole-genome doubling (WGD) is common in human cancers, occurring early in
tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour …
tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour …
Whole-genome duplication shapes the aneuploidy landscape of human cancers
Aneuploidy is a hallmark of cancer with tissue-specific prevalence patterns that suggest it
plays a driving role in cancer initiation and progression. However, the contribution of …
plays a driving role in cancer initiation and progression. However, the contribution of …
Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution
The contribution of whole-genome doubling to chromosomal instability (CIN) and tumor
evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable …
evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable …
DNA secondary structures and epigenetic determinants of cancer genome evolution
An unstable genome is a hallmark of many cancers. It is unclear, however, whether some
mutagenic features driving somatic alterations in cancer are encoded in the genome …
mutagenic features driving somatic alterations in cancer are encoded in the genome …
[HTML][HTML] High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
The impact of somatic structural variants (SVs) on gene expression in cancer is largely
unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes …
unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes …
Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells
AY Kuznetsova, K Seget, GK Moeller, MS de Pagter… - Cell cycle, 2015 - Taylor & Francis
Up to 80% of human cancers, in particular solid tumors, contain cells with abnormal
chromosomal numbers, or aneuploidy, which is often linked with marked chromosomal …
chromosomal numbers, or aneuploidy, which is often linked with marked chromosomal …
[HTML][HTML] Signatures of copy number alterations in human cancer
Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
Whole-genome doubling in tissues and tumors
MA Vittoria, RJ Quinton, NJ Ganem - Trends in Genetics, 2023 - cell.com
The overwhelming majority of proliferating somatic human cells are diploid, and this
genomic state is typically maintained across successive cell divisions. However, failures in …
genomic state is typically maintained across successive cell divisions. However, failures in …