[HTML][HTML] Classification of chemicals as respiratory allergens based on human data: Requirements and practical considerations

MA Pemberton, I Kimber - Regulatory Toxicology and Pharmacology, 2021 - Elsevier
Occupational asthma is an important health problem that can include exacerbation of
existing asthma, or induce new asthma either through allergic sensitisation, or non …

Chemical respiratory allergy and occupational asthma: what are the key areas of uncertainty?

D Isola, I Kimber, K Sarlo, J Lalko… - Journal of Applied …, 2008 - Wiley Online Library
There is increasing concern about the association of respiratory disease with indoor air
quality and environmental atmospheric pollution. Associated with this is the fact that in many …

[HTML][HTML] Behaviour of chemical respiratory allergens in novel predictive methods for skin sensitisation

D Basketter, A Poole, I Kimber - Regulatory Toxicology and Pharmacology, 2017 - Elsevier
Asthma resulting from sensitisation of the respiratory tract to chemicals is an important
occupational health issue, presenting many toxicological challenges. Most importantly there …

Inter‐relationships between different classes of chemical allergens

RJ Dearman, DA Basketter… - Journal of applied …, 2013 - Wiley Online Library
Although allergic sensitization of the respiratory tract induced by chemicals is not as
common as skin sensitization, it is nevertheless an important occupational health issue …

[HTML][HTML] Identification of true chemical respiratory allergens: Current status, limitations and recommendations

MA Pemberton, JHE Arts, I Kimber - Regulatory Toxicology and …, 2024 - Elsevier
Asthma in the workplace is an important occupational health issue. It comprises various
subtypes: occupational asthma (OA; both allergic asthma and irritant-induced asthma) and …

Chemical respiratory allergy: reverse engineering an adverse outcome pathway

I Kimber, RJ Dearman, DA Basketter, DR Boverhof - Toxicology, 2014 - Elsevier
Allergic sensitisation of the respiratory tract by chemicals is associated with rhinitis and
asthma and remains an important occupational health issue. Although less than 80 …

A proposed screen for evaluating low‐molecular‐weight chemicals as potential respiratory allergens

DL Gauggel, K Sarlo, TN Asquith - Journal of applied …, 1993 - Wiley Online Library
Allergic asthma can result when reactive low‐molecular‐weight chemicals (LMWCs)
haptenate carrier proteins to form immunogenic conjugates, which then induce specific …

Respiratory sensitization and allergy: current research approaches and needs

DR Boverhof, R Billington, BB Gollapudi… - Toxicology and Applied …, 2008 - Elsevier
There are currently no accepted regulatory models for assessing the potential of a
substance to cause respiratory sensitization and allergy. In contrast, a number of models …

A tier approach for evaluating the respiratory allergenicity of low molecular weight chemicals

K Sarlo, ED Clark - Toxicological Sciences, 1992 - academic.oup.com
Abstract A Tier Approach for Evaluating the Respiratory Allergenicity of Low Molecular
Weight Chemicals. SARLO, K., AND CLARK, ED (1992). Fundam. Appl. Toxicol. 18, 107 …

Chemical respiratory allergy, IgE and the relevance of predictive test methods: a commentary

I Kimber, EV Warbrick… - Human & experimental …, 1998 - journals.sagepub.com
Occupational asthma resulting from allergic sensitization of the respiratory tract is an
important health problem. 1 Both proteins and chemicals have been implicated as causative …