Impairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer's disease
R Mao, M Hu, X Liu, L Ye, B Xu, M Sun, S Xu… - Cell Communication and …, 2024 - Springer
Abstract Background Patients with Alzheimer's disease (AD) are often co-morbid with
unprovoked seizures, making clinical diagnosis and management difficult. Although it has …
unprovoked seizures, making clinical diagnosis and management difficult. Although it has …
Inhibitory neural network's impairments at hippocampal CA1 LTP in an aged transgenic mouse model of Alzheimer's disease
HJ Seo, JE Park, SM Choi, T Kim, SH Cho… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a rapid
accumulation of amyloid β (Aβ) protein in the hippocampus, which impairs synaptic …
accumulation of amyloid β (Aβ) protein in the hippocampus, which impairs synaptic …
Unsupervised excitation: GABAergic dysfunctions in Alzheimer's disease
EA Giovannetti, M Fuhrmann - Brain research, 2019 - Elsevier
Alzheimer's disease (AD) is characterized by the classical hallmarks of Aβ-deposition and
tau-pathology that are thought to ultimately lead to synapse and neuron loss. Although long …
tau-pathology that are thought to ultimately lead to synapse and neuron loss. Although long …
[HTML][HTML] Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Dysregulation of
glutamate transporters has been a common finding across animal models of epilepsy and in …
glutamate transporters has been a common finding across animal models of epilepsy and in …
Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer's disease
MS Albuquerque, I Mahar, MA Davoli… - Frontiers in Aging …, 2015 - frontiersin.org
Hippocampal network activity is predominantly coordinated by γ-amino-butyric acid (GABA)
ergic neurons. We have previously hypothesized that the altered excitability of hippocampal …
ergic neurons. We have previously hypothesized that the altered excitability of hippocampal …
Epilepsy and Alzheimer's Disease: Potential mechanisms for an association
FS Giorgi, LF Saccaro, CL Busceti, F Biagioni… - Brain Research …, 2020 - Elsevier
Alzheimer's Disease (AD) and epilepsy are common neurological diseases. The prevalence
of epilepsy in AD patients is higher than in healthy subjects, but identifying the reasons for …
of epilepsy in AD patients is higher than in healthy subjects, but identifying the reasons for …
Brain networks and epilepsy development in patients with Alzheimer disease
Introduction This study aimed to investigate the association between brain networks and
epilepsy development in patients with Alzheimer disease (AD). Methods We enrolled …
epilepsy development in patients with Alzheimer disease (AD). Methods We enrolled …
Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease
Alzheimer's disease (AD) can increase the risk of epilepsy by up to 10‐fold compared to
healthy age‐matched controls. However, the pathological mechanisms that underlie this …
healthy age‐matched controls. However, the pathological mechanisms that underlie this …
Epileptogenesis causes acute and chronic increases in GABAA receptor endocytosis that contributes to the induction and maintenance of seizures in the hippocampal …
RE Blair, S Sombati, DC Lawrence, BD McCay… - … of Pharmacology and …, 2004 - ASPET
Altered GABAergic inhibitory tone has been observed in association with a number of both
acute and chronic models of epilepsy and is believed to be the result, in part, of a decrease …
acute and chronic models of epilepsy and is believed to be the result, in part, of a decrease …
Temporal lobe epilepsy and Alzheimer's disease: from preclinical to clinical evidence of a strong association
Increasing evidence coming from both experimental and humans' studies strongly suggest
the existence of a link between epilepsy, in particular temporal lobe epilepsy (TLE), and …
the existence of a link between epilepsy, in particular temporal lobe epilepsy (TLE), and …
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