Ribonucleases (RNases) are mediators in most reactions of RNA metabolism. In recent
years, there has been a surge of new information about RNases and the roles they play in …

Probably every RNA molecule undergoes some reaction that requires the action of a
ribonuclease (RNase). As the details and complexity of RNA metabolism have emerged in …

Ribozymes, or catalytic RNAs, were discovered a little more than 15 years ago. They are
found in the organelles of plants and lower eukaryotes, in amphibians, in prokaryotes, in …

In recent years there has been a dramatic shift in our thinking about ribonucleases
(RNases). Although they were once considered to be nonspecific, degradative enzymes, it is …

The maturation and degradation of RNA molecules are essential features of the mechanism
of gene expression, and provide the two main points for post-transcriptional regulation. Cells …

Publisher Summary Ribonucleases (RNases) may be defined as phosphodiesterases that
attack the internucleotide bonds in RNA and its products but not those in DNA or simple …

It is widely recognized that RNA degradation plays a critical role in gene regulation when
fast adaptation of cell growth is required to respond to stress and changing environmental …

Small endonucleolytic ribozymes promote the self-cleavage of their own phosphodiester
backbone at a specific linkage. The structures of and the reactions catalysed by members of …

RNA processing and degradation are key processes in the control of transcript accumulation
and thus in the control of gene expression. In Escherichia coli, the underlying mechanisms …

Escherichia coli RNase R, a 3′→ 5′ exoribonuclease homologous to RNase II, was
overexpressed and purified to near homogeneity in its native untagged form by a rapid …