Heart failure (HF) is a leading cause of death and repeated hospitalizations and often
involves cardiac mitochondrial dysfunction. However, the underlying mechanisms largely …

Aims Heart failure is associated with decreased myocardial fatty acid oxidation capacity and
has been likened to energy starvation. Increased fatty acid availability results in an induction …

Background Energy metabolism and substrate selection are key aspects of correct
myocardial mechanical function. Myocardial preference for oxidizable substrates changes in …

Despite recent advances in therapy, heart failure remains a major cause of mortality and
morbidity and is a growing healthcare burden worldwide. Alterations in myocardial energy …

Alterations in cardiac energy metabolism after a myocardial infarction contribute to the
severity of heart failure (HF). Although fatty acid oxidation can be impaired in HF, it is unclear …

Background Reduced fatty acid oxidation (FAO) is a hallmark of metabolic remodeling in
heart failure. Enhancing mitochondrial long-chain fatty acid uptake by Acetyl-CoA …

Myocardial fuel and energy metabolic derangements contribute to the pathogenesis of heart
failure. Recent evidence implicates posttranslational mechanisms in the energy metabolic …

Background: Diet-induced obesity leads to metabolic heart disease (MHD) characterized by
increased oxidative stress that may cause oxidative post-translational modifications (OPTM) …

Succinylation is a post-translational modification of protein lysine residues with succinyl
groups derived from succinyl CoA. Succinylation is considered a significant post …

CoA (coenzyme A) and its derivatives have a critical role in regulating cardiac energy
metabolism. This includes a key role as a substrate and product in the energy metabolic …