Obstacles and opportunities in Alzheimer's clinical trial recruitment

JL Watson, L Ryan, N Silverberg, V Cahan… - Health …, 2014 - healthaffairs.org
The 2012 National Plan to Address Alzheimer's Disease set an ambitious goal: to both
prevent and effectively treat Alzheimer's disease by 2025. To reach this goal, tens of …

Recommendations to address key recruitment challenges of Alzheimer's disease clinical trials

JB Langbaum, J Zissimopoulos, R Au… - Alzheimer's & …, 2023 - Wiley Online Library
Clinical trials for Alzheimer's disease (AD) are slower to enroll study participants, take longer
to complete, and are more expensive than trials in most other therapeutic areas. The …

Study partners: essential collaborators in discovering treatments for Alzheimer's disease

EA Largent, J Karlawish, JD Grill - Alzheimer's research & therapy, 2018 - Springer
Background Global leaders have set an ambitious goal of developing interventions to
effectively treat or prevent Alzheimer's disease by 2025. Case presentation Achieving this …

Challenges to and facilitators of recruitment to an Alzheimer's disease clinical trial: a qualitative interview study

C Clement, LE Selman, PG Kehoe… - Journal of …, 2019 - content.iospress.com
Background: Low participation in clinical trials is a major challenge to advancing clinical
Alzheimer's disease (AD) research and care. Factors influencing recruitment to AD trials are …

Facilitating Alzheimer disease research recruitment

JD Grill, JE Galvin - Alzheimer Disease & Associated Disorders, 2014 - journals.lww.com
Alzheimer disease (AD) research faces challenges to successful enrollment, especially to
clinical trials and biomarker studies. Failure to recruit the planned number of participants in a …

Constructing a local potential participant registry to improve Alzheimer's disease clinical research recruitment

JD Grill, D Hoang, DL Gillen, CG Cox… - Journal of …, 2018 - content.iospress.com
Potential participant registries are tools to address the challenge of slow recruitment to
clinical research. In particular, registries may aid recruitment to secondary prevention clinical …

Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials

JD Grill, J Karlawish - Alzheimer's research & therapy, 2010 - Springer
Among the key challenges in Alzheimer's disease drug development is the timely
completion of clinical trials. Unfortunately, clinical trials often suffer from slow or insufficient …

[HTML][HTML] Re-engineering Alzheimer clinical trials: Global Alzheimer's Platform network

J Cummings, P Aisen, R Barton, J Bork… - The journal of …, 2016 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) drug development is costly, time-consuming, and inefficient. Trial
site functions, trial design, and patient recruitment for trials all require improvement. The …

[HTML][HTML] Together we make the difference: national strategy for recruitment and participation in Alzheimer's and related dementias clinical research

CL Elliott - Ethnicity & disease, 2020 - ncbi.nlm.nih.gov
Abstract The National Alzheimer's Project Act identifies the effective treatment and
prevention of Alzheimer's by 2025 as an urgent public health mission. This priority is …

Clinical research participation among aging adults enrolled in an Alzheimer's Disease Center research registry

AL Jefferson, S Lambe, C Chaisson… - Journal of …, 2011 - content.iospress.com
In light of our limited understanding of what motivates older adults to participate in clinical
studies of Alzheimer's disease (AD), the current study examines incentives and barriers to …