Brain extracellular matrix (ECM) structure mediates many aspects of neural development
and function. Probing structural changes in brain ECM could thus provide insights into …

Microglia are implicated in aging, neurodegeneration, and Alzheimer's disease (AD).
Traditional, low-plex, imaging methods fall short of capturing in situ cellular states and …

Repetitive mild traumatic brain injuries (rmTBIs) are serious trauma events responsible for
the development of numerous neurodegenerative disorders. A major challenge in …

Oligodendrocytes exert a profound influence on neural circuits by accelerating action
potential conduction, altering excitability, and providing metabolic support. As …

Neurodegenerative disorders are characterized by phenotypic changes and hallmark
proteopathies. Quantifying these in archival human brain tissues remains indispensable for …

Brain microenvironment plays an important role in neurodevelopment and pathology, where
the extracellular matrix (ECM) and soluble factors modulate multiple cellular processes …

Understanding the mechanisms that control critical biological events of neural cell
populations, such as proliferation, differentiation, or cell fate decisions, will be crucial to …

Current approaches for dynamic profiling of single cells rely on dissociated cultures, which
lack important biological features existing in tissues. Organotypic slice cultures preserve …

Age-related cognitive decline is a serious health concern in our aging society. Decreased
cognitive function observed during healthy brain aging is most likely caused by changes in …

Nanoparticle platforms are being intensively investigated for neurological applications.
Current biological models used to identify clinically relevant materials have major limitations …