Background Late-stage breast cancer preferentially metastasises to bone; despite advances
in targeted therapies, this condition remains incurable. The lack of clinically relevant models …

Bone is established as the preferred site of breast cancer metastasis. However, the precise
mechanisms responsible for this preference remain unidentified. In order to improve …

Bone metastasis is a complication that occurs in 80% of women with advanced breast
cancer. Despite the prevalence of bone metastatic disease, the avenues for its clinical …

Breast cancer frequently metastasizes to bone, where it takes a significant toll on quality of
life. Models of bone metastasis are needed in order to better understand the process of bone …

Bone metastases cause significant morbidity and mortality in late-stage breast cancer
patients and are currently considered incurable. Investigators rely on translational models to …

A major dilemma facing patients with breast cancer is how to decide between over treating
indolent tumors and failing to adequately treat aggressive, potentially lethal cancers …

This chapter is designed to provide a comprehensive overview outlining the different in vivo
models available for research into breast cancer bone metastasis. The main focus is to …

In practice, investigations for bone metastasis of breast cancer rely heavily on models in
vivo. Lacking of such ideal model makes it difficult to study the whole process or accurate …

Bone metastasis is a complex process that needs to be better understood in order to help
clinicians prevent and treat it. Xenografts using patient-derived material (PDX) rather than …

Breast cancer patients with advanced disease exhibit bone metastases, leading to the
formation of osteolytic lesions for which the only currently available treatments are palliative …