A method for genome-wide genealogy estimation for thousands of samples

L Speidel, M Forest, S Shi, SR Myers - Nature genetics, 2019 - nature.com
Abstract Knowledge of genome-wide genealogies for thousands of individuals would
simplify most evolutionary analyses for humans and other species, but has remained …

Bayesian inference of ancient human demography from individual genome sequences

I Gronau, MJ Hubisz, B Gulko, CG Danko, A Siepel - Nature genetics, 2011 - nature.com
Whole-genome sequences provide a rich source of information about human evolution.
Here we describe an effort to estimate key evolutionary parameters based on the whole …

Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans

A Keinan, JC Mullikin, N Patterson, D Reich - Nature genetics, 2007 - nature.com
Large data sets on human genetic variation have been collected recently, but their
usefulness for learning about history and natural selection has been limited by biases in the …

Genotype, haplotype and copy-number variation in worldwide human populations

M Jakobsson, SW Scholz, P Scheet, JR Gibbs… - Nature, 2008 - nature.com
Genome-wide patterns of variation across individuals provide a powerful source of data for
uncovering the history of migration, range expansion, and adaptation of the human species …

Inference of human population history from individual whole-genome sequences

H Li, R Durbin - Nature, 2011 - nature.com
The history of human population size is important for understanding human evolution.
Various studies,,,, have found evidence for a founder event (bottleneck) in East Asian and …

Biobank-scale inference of ancestral recombination graphs enables genealogical analysis of complex traits

BC Zhang, A Biddanda, ÁF Gunnarsson, F Cooper… - Nature Genetics, 2023 - nature.com
Genome-wide genealogies compactly represent the evolutionary history of a set of genomes
and inferring them from genetic data has the potential to facilitate a wide range of analyses …

Inferring human population size and separation history from multiple genome sequences

S Schiffels, R Durbin - Nature genetics, 2014 - nature.com
The availability of complete human genome sequences from populations across the world
has given rise to new population genetic inference methods that explicitly model ancestral …

Human genome sequence variation and the influence of gene history, mutation and recombination

DE Reich, SF Schaffner, MJ Daly, G McVean… - Nature …, 2002 - nature.com
Variation in the human genome sequence is key to understanding susceptibility to disease
in modern populations and the history of ancestral populations. Unlocking this information …

[HTML][HTML] Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping

J Xing, WS Watkins, A Shlien, E Walker, CD Huff… - Genomics, 2010 - Elsevier
High-throughput genotyping data are useful for making inferences about human
evolutionary history. However, the populations sampled to date are unevenly distributed …

[HTML][HTML] A map of human genome variation from population scale sequencing

1000 Genomes Project Consortium - Nature, 2010 - ncbi.nlm.nih.gov
Abstract The 1000 Genomes Project aims to provide a deep characterisation of human
genome sequence variation as a foundation for investigating the relationship between …