A true discrepancy between the effect of systolic blood pressure (SBP) and diastolic blood
pressure (DBP) on cardiovascular (CV) outcomes remains unclear. This study performed …

Abstract The 2017 American College of Cardiology/American Heart Association (ACC/AHA)
blood pressure (BP) guidelines lowered the hypertension threshold to≥ 130/80 mmHg, but …

Background: Mendelian randomization studies of systolic blood pressure (SBP) can assess
the shape and strength of the associations of genetically predicted differences in SBP with …

Background: Recent clinical guidelines support intensive blood pressure treatment targets.
However, observational data suggest that excessive diastolic blood pressure (DBP) …

Background The causal relevance of elevated blood pressure for several cardiovascular
diseases (CVDs) is uncertain, as is the population impact of blood pressure lowering. This …

Observational studies exploring whether there is a nonlinear effect of blood pressure on
cardiovascular disease (CVD) risk are hindered by confounding. This limitation can be …

This study aims to evaluate the causal association of blood pressure (BP) with
cardiovascular diseases (CVDs). Two-sample Mendelian randomization was performed …

Systolic and diastolic blood pressure (S/DBP) are highly correlated modifiable risk factors for
cardiovascular disease (CVD). We report here a bidirectional Mendelian Randomization …

Background: Elevated blood pressure (BP) was associated with higher risk of heart failure,
but the relationship between BP-lowering via antihypertensive drugs and diminution of heart …

Background Elevated blood pressure is a major cause of cardiovascular morbidity and
mortality. However, it is not known whether midlife blood pressure affects later life …