Applications of deep learning in understanding gene regulation

Z Li, E Gao, J Zhou, W Han, X Xu, X Gao - Cell Reports Methods, 2023 - cell.com
Gene regulation is a central topic in cell biology. Advances in omics technologies and the
accumulation of omics data have provided better opportunities for gene regulation studies …

A hybrid deep learning framework for gene regulatory network inference from single-cell transcriptomic data

M Zhao, W He, J Tang, Q Zou… - Briefings in bioinformatics, 2022 - academic.oup.com
Inferring gene regulatory networks (GRNs) based on gene expression profiles is able to
provide an insight into a number of cellular phenotypes from the genomic level and reveal …

Deep learning for regulatory genomics

Y Park, M Kellis - Nature biotechnology, 2015 - nature.com
Deep learning for regulatory genomics | Nature Biotechnology Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Deep learning for computational biology

C Angermueller, T Pärnamaa, L Parts… - Molecular systems …, 2016 - embopress.org
Technological advances in genomics and imaging have led to an explosion of molecular
and cellular profiling data from large numbers of samples. This rapid increase in biological …

Computational biology: deep learning

W Jones, K Alasoo, D Fishman… - Emerging Topics in Life …, 2017 - portlandpress.com
Deep learning is the trendiest tool in a computational biologist's toolbox. This exciting class
of methods, based on artificial neural networks, quickly became popular due to its …

Modeling genomic regulatory networks with big data

H Bolouri - Trends in Genetics, 2014 - cell.com
High-throughput sequencing, large-scale data generation projects, and web-based cloud
computing are changing how computational biology is performed, who performs it, and what …

Recent advances of deep learning in bioinformatics and computational biology

B Tang, Z Pan, K Yin, A Khateeb - Frontiers in genetics, 2019 - frontiersin.org
Extracting inherent valuable knowledge from omics big data remains as a daunting problem
in bioinformatics and computational biology. Deep learning, as an emerging branch from …

Predictive analyses of regulatory sequences with EUGENe

A Klie, D Laub, JV Talwar, H Stites, T Jores… - Nature Computational …, 2023 - nature.com
Deep learning has become a popular tool to study cis-regulatory function. Yet efforts to
design software for deep-learning analyses in regulatory genomics that are findable …

Towards more realistic simulated datasets for benchmarking deep learning models in regulatory genomics

EI Prakash, A Shrikumar… - Machine Learning in …, 2022 - proceedings.mlr.press
Deep neural networks and support vector machines have been shown to accurately predict
genome-wide signals of regulatory activity from raw DNA sequences. These models are …

A guide to machine learning for biologists

JG Greener, SM Kandathil, L Moffat… - Nature reviews Molecular …, 2022 - nature.com
The expanding scale and inherent complexity of biological data have encouraged a growing
use of machine learning in biology to build informative and predictive models of the …