How hematopoietic stem cells (HSCs) coordinate their divisional axis and whether this
orientation is important for stem cell–driven hematopoiesis is poorly understood. Single-cell …

Altered expression and activity of histone deacetylases (HDACs) have been correlated with
tumorigenesis. Inhibitors of HDACs (HDACi) induce acetylation of histone and non-histone …

Shwachman–Diamond syndrome (SDS) is a bone marrow failure (BMF) syndrome
associated with an increased risk of myelodysplasia and leukemia. The molecular …

Hematopoiesis is a finely regulated process in vertebrates under both homeostatic and
stress conditions. By whole exome sequencing, we studied the genomics of acute …

HIRA is a histone chaperone that deposits the histone variant H3. 3 in transcriptionally active
genes. In DiGeorge syndromes, a DNA stretch encompassing HIRA is deleted. The …

Abstract Background The Dbl family guanine nucleotide exchange factor ARHGEF10 was
originally identified as the product of the gene associated with slowed nerve-conduction …

Shwachman-Diamond syndrome (SDS) is an inherited multi-organ disorder with bone
marrow failure (BMF), which may include neutropenia, anemia, and thrombocytopenia, as …

Hematopoietic stem cells (HSCs) can self-renew and differentiate for the entire life of an
organism to produce new blood cells when needed. This process is regulated by …

Abstract Background: Shwachman-Diamond syndrome (SDS) is an inherited bone marrow
failure disorder characterized by varying degrees of cytopenia and a high propensity for …

Shwachman-Diamond syndrome (SDS) is an autosomal recessive disorder characterized by
bone marrow failure and a striking propensity to develop poor prognosis myelodysplastic …