Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia
Leukotriene-C 4 synthase (LTC 4 S) generates LTC 4 from arachidonic acid metabolism.
LTC 4 is a proinflammatory factor that acts on plasma membrane cysteinyl leukotriene …
LTC 4 is a proinflammatory factor that acts on plasma membrane cysteinyl leukotriene …
Store-Independent Orai1/3 Channels Activated by Intracrine LeukotrieneC4 Role in Neointimal Hyperplasia
Rationale: Through largely unknown mechanisms, Ca2+ signaling plays important roles in
vascular smooth muscle cell (VSMC) remodeling. Orai1-encoded store-operated Ca2+ entry …
vascular smooth muscle cell (VSMC) remodeling. Orai1-encoded store-operated Ca2+ entry …
Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels
We recently showed, in primary vascular smooth muscle cells (VSMCs), that the platelet-
derived growth factor activates canonical store-operated Ca 2+ entry and Ca 2+ release …
derived growth factor activates canonical store-operated Ca 2+ entry and Ca 2+ release …
Orai3 surface accumulation and calcium entry evoked by vascular endothelial growth factor
J Li, AF Bruns, B Hou, B Rode, PJ Webster… - … and Vascular Biology, 2015 - Am Heart Assoc
Objective—Vascular endothelial growth factor (VEGF) acts, in part, by triggering calcium ion
(Ca2+) entry. Here, we sought understanding of a Synta66-resistant Ca2+ entry pathway …
(Ca2+) entry. Here, we sought understanding of a Synta66-resistant Ca2+ entry pathway …
Orai1-Mediated ICRAC Is Essential for Neointima Formation After Vascular Injury
Rationale: The molecular correlate of the calcium release-activated calcium current
(ICRAC), the channel protein Orai1, is upregulated in proliferative vascular smooth muscle …
(ICRAC), the channel protein Orai1, is upregulated in proliferative vascular smooth muscle …
ORAI1 Ca2+ Channel as a Therapeutic Target in Pathological Vascular Remodelling
H Shawer, K Norman, CW Cheng, R Foster… - Frontiers in Cell and …, 2021 - frontiersin.org
In the adult, vascular smooth muscle cells (VSMC) are normally physiologically quiescent,
arranged circumferentially in one or more layers within blood vessel walls. Remodelling of …
arranged circumferentially in one or more layers within blood vessel walls. Remodelling of …
Orai1 and CRAC Channel Dependence of VEGF-Activated Ca2+ Entry and Endothelial Tube Formation
Rationale: Orai1 and the associated calcium release-activated calcium (CRAC) channel
were discovered in the immune system. Existence also in endothelial cells has been …
were discovered in the immune system. Existence also in endothelial cells has been …
SARAF and Orai1 contribute to endothelial cell activation and angiogenesis
Angiogenesis is a multistep process that controls endothelial cells (ECs) functioning to form
new blood vessels from preexisting vascular beds. This process is tightly regulated by pro …
new blood vessels from preexisting vascular beds. This process is tightly regulated by pro …
SGK1 up-regulates Orai1 expression and VSMC migration during neointima formation after arterial injury
B Walker-Allgaier, M Schaub, I Alesutan… - Thrombosis and …, 2017 - thieme-connect.com
Neointima formation following vascular remodelling requires complex, incompletely
understood cellular signalling in inflammatory cells and vascular smooth muscle cells …
understood cellular signalling in inflammatory cells and vascular smooth muscle cells …
p38 MAPK activation and STIM1-Orai3 association mediate TRPC6 externalization
P Chaudhuri, P Putta… - American Journal of …, 2023 - journals.physiology.org
Endothelial cell (EC) migration is critical for the repair of monolayer disruption following
angioplasties, but migration is inhibited by lipid oxidation products, including …
angioplasties, but migration is inhibited by lipid oxidation products, including …