Minocycline: far beyond an antibiotic

N Garrido‐Mesa, A Zarzuelo… - British journal of …, 2013 - Wiley Online Library
Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic
use for over 30 years because of its antibiotic properties against both gram‐positive and …

What is behind the non-antibiotic properties of minocycline?

N Garrido-Mesa, A Zarzuelo, J Galvez - Pharmacological research, 2013 - Elsevier
Minocycline is a second-generation, semi-synthetic tetracycline that has been in use in
therapy for over 30 years for its antibiotic properties against both Gram-positive and Gram …

The potential of minocycline for neuroprotection in human neurologic disease

D Zemke, A Majid - Clinical neuropharmacology, 2004 - journals.lww.com
Minocycline is a member of the tetracycline class of molecules with broad-spectrum
antibiotic activity. The unique properties of minocycline result in increased tissue distribution …

Minocycline and neurodegenerative diseases

HS Kim, YH Suh - Behavioural brain research, 2009 - Elsevier
Minocycline is a semi-synthetic, second-generation tetracycline analog which is effectively
crossing the blood–brain barrier, effective against gram-positive and-negative infections. In …

Minocycline and doxycycline: more than antibiotics

S Singh, D Khanna, S Kalra - Current Molecular Pharmacology, 2021 - ingentaconnect.com
Minocycline and doxycycline both are second-generation tetracycline antibiotics with similar
chemical structures and comparable antibacterial spectrum. Minocycline has also emerged …

Tetracyclines: drugs with huge therapeutic potential

F Bahrami, DL Morris… - Mini reviews in …, 2012 - ingentaconnect.com
Tetracyclines are an amazing class of chemical agents with multiple therapeutic potential.
Structural modification of the original natural tetracyclines led to the synthesis and …

Rise and fall of minocycline in neuroprotection: need to promote publication of negative results

E Diguet, CE Gross, F Tison, E Bezard - Experimental neurology, 2004 - Elsevier
Initial studies conducted on the neuroprotective effects of minocycline, a second-generation
tetracycline, in experimental models of neurodegeneration gave promising results. However …

Minocycline in neurodegenerative and psychiatric diseases: an update

D Romero‐Miguel, N Lamanna‐Rama… - European Journal of …, 2021 - Wiley Online Library
Background and purpose Minocycline is a broad‐spectrum antibiotic, effective as a chronic
treatment for recurrent bacterial infections. Beyond its antibiotic action, minocycline also has …

[HTML][HTML] Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: Back to the future

A Asadi, M Abdi, E Kouhsari, P Panahi… - Journal of global …, 2020 - Elsevier
Objectives The increasing crisis regarding multidrug-resistant (MDR) and extensively drug-
resistant microorganisms leads to appealing therapeutic options. Methods During the last 30 …

Minocycline: a review of its antibacterial and pharmacokinetic properties and therapeutic use

RN Brogden, TM Speight, GS Avery - Drugs, 1975 - Springer
Synopsis: Minocycline 2 is a semi-synthetic tetracycline derivative which is well absorbed
and distributed in body tissues and is suitable for twice daily administration. It appears to be …