Many human genetic associations with resistance to malaria have been reported, but few
have been reliably replicated. We collected data on 11,890 cases of severe malaria due to …

The frequencies of low-activity alleles of glucose-6-phosphate dehydrogenase in humans
are highly correlated with the prevalence of malaria. These “deficiency” alleles are thought …

Several lines of evidence link glucose-6-phosphate dehydrogenase (G6PD) deficiency to
protection from severe malaria. Early reports suggested most G6PD deficiency in sub …

Background Clinical association studies have yielded varied results regarding the impact of
glucose-6-phosphate dehydrogenase (G6PD) deficiency upon susceptibility to malaria …

The human genetic factors that affect resistance to infectious disease are poorly understood.
Here we report a genome-wide association study in 17,000 severe malaria cases and …

Malaria is a major killer of children worldwide and the strongest known force for evolutionary
selection in the recent history of the human genome. The past decade has seen growing …

Background Glucose-6-phosphate dehydrogenase (G6PD) is important in the control of
oxidant stress in erythrocytes, the host cells for Plasmodium falciparum. Mutations in this …

Malaria causes approximately one million fatalities per year, mostly among African children.
Although highlighted by the strong protective effect of the sickle-cell trait,, the full impact of …

G6PD deficiency is a common hemolytic genetic disorder, particularly in the areas endemic
to malaria. Individuals are generally asymptomatic and hemolytic anemia occurs when some …

Glucose-6-phosphate dehydrogenase (G6PD) mutations that result in reduced enzyme
activity have been implicated in malarial resistance and constitute one of the best examples …