Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …

Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

Within the last two decades, the advancement in cellular and cancer biology research can
be defined by a few foundational pillars—one of the most important ones being the advent of …

Research on molecular targeted therapy of tumors is booming, and novel targeted therapy
drugs are constantly emerging. Small molecule targeted compounds, novel targeted therapy …

The identification of molecular targets and the growing knowledge of their cellular functions
have led to the development of small molecule inhibitors as a major therapeutic class for …

A high incidence of cancer has given rise to the development of more anti-tumor drugs. From
2015 to 2020, fifty-six new small-molecule anticancer drugs, divided into ten categories …

Selective small-molecule kinase inhibitors have emerged over the past decade as an
important class of anti-cancer agents, and have demonstrated impressive clinical efficacy in …

Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of
the improvements in the life quality of patients, their effectiveness is compromised by several …

The discovery and development of small molecule cancer drugs has been revolutionised
over the last decade. Most notably, we have moved from a one-size-fits-all approach that …

With advances in modern technologies and growing understanding of cellular biology, a
variety of new mechanisms and molecular antagonists are currently being pursued in the …