Endoplasmic reticulum stress (ERS) is a protective response to restore protein homeostasis
by activating the unfolded protein response (UPR). However, UPR can trigger cell death …

Uncontrolled endoplasmic reticulum (ER) stress responses are proposed to contribute to the
pathology of chronic inflammatory diseases such as type 2 diabetes or atherosclerosis …

Inflammation is the result of a complex network of cellular and molecular interactions and
mechanisms that facilitate immune protection against intrinsic and extrinsic stimuli …

The endoplasmic reticulum (ER) is an important organelle that regulates several
fundamental cellular processes, and ER dysfunction has implications for many intracellular …

Inflammation, as a common immune response to various infections or injuries, can cause
many dangerous and complicated diseases. Inflammasome is a protein complex playing a …

Diverse pathogen-and damage-associated stresses drive inflammation via activation of the
multimolecular NLRP3–inflammasome complex. How the effects of diverse stimuli are …

The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-
containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and …

The NLRP3 inflammasome is a multi-molecular complex that acts as a molecular platform to
mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and release in cells …

Almost all human diseases are strongly associated with inflammation, and a deep
understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome …

In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3
(NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in …