BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity

P Kowiański, G Lietzau, E Czuba, M Waśkow… - Cellular and molecular …, 2018 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and
extensively studied neurotrophins in the mammalian brain. Among its prominent functions …

[HTML][HTML] Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders

S Camuso, P La Rosa, MT Fiorenza, S Canterini - Neurobiology of disease, 2022 - Elsevier
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
mammalian brain, essential not only to the development of the central nervous system but …

A simple role for BDNF in learning and memory?

C Cunha, R Brambilla, KL Thomas - Frontiers in molecular …, 2010 - frontiersin.org
Since its discovery almost three decades ago, the secreted neurotrophin brain-derived
neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of …

BDNF and synaptic plasticity, cognitive function, and dysfunction

B Lu, G Nagappan, Y Lu - Neurotrophic factors, 2014 - Springer
Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high
level of expression in the brain and its potent effects on synapses. It is now widely accepted …

Cellular and molecular mechanisms of the brain-derived neurotrophic factor in physiological and pathological conditions

V Begni, MA Riva, A Cattaneo - Clinical Science, 2017 - portlandpress.com
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a key role in the
central nervous system, promoting synaptic plasticity, neurogenesis and neuroprotection …

Actions of brain-derived neurotrophin factor in the neurogenesis and neuronal function, and its involvement in the pathophysiology of brain diseases

T Numakawa, H Odaka, N Adachi - International journal of molecular …, 2018 - mdpi.com
It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a
variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the …

Brain‐derived neurotrophic factor and the development of structural neuronal connectivity

S Cohen‐Cory, AH Kidane, NJ Shirkey… - Developmental …, 2010 - Wiley Online Library
During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the developing nervous system …

Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases

KF Azman, R Zakaria - International journal of molecular sciences, 2022 - mdpi.com
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …

Neurobiological actions by three distinct subtypes of brain-derived neurotrophic factor: Multi-ligand model of growth factor signaling

T Mizui, Y Ishikawa, H Kumanogoh, M Kojima - Pharmacological research, 2016 - Elsevier
Brain-derived neurotrophic factor (BDNF) is one of the most active members of the
neurotrophin family. BDNF not only regulates neuronal survival and differentiation, but also …

Form follows function: BDNF and its involvement in sculpting the function and structure of synapses

M Zagrebelsky, M Korte - Neuropharmacology, 2014 - Elsevier
Neurotrophins are essential for multiple aspects of neuronal development and function.
Especially BDNF (brain-derived-neurotrophic-factor) has been shown to play an important …