PPARγ in Atherosclerotic Endothelial Dysfunction: Regulatory Compounds and PTMs

J Luan, X Ji, L Liu - International Journal of Molecular Sciences, 2023 - mdpi.com
The formation of atherosclerotic plaques is one of the main sources of cardiovascular
disease. In addition to known risk factors such as dyslipidemia, diabetes, obesity, and …

Peroxisome Proliferator-Activated Receptor??(PPAR??) and Atherosclerosis

I Gouni-Berthold, W Krone - Current Drug Targets …, 2005 - ingentaconnect.com
The peroxisome proliferator-activated receptors (PPARs) α, β/δ and γ are ligand-activated
transcription factors belonging to the nuclear receptor superfamily. PPARs heterodimerize …

Pharmacological utility of PPAR modulation for angiogenesis in cardiovascular disease

N Wagner, KD Wagner - International Journal of Molecular Sciences, 2023 - mdpi.com
Peroxisome proliferator activated receptors, including PPARα, PPARβ/δ, and PPARγ, are
ligand-activated transcription factors belonging to the nuclear receptor superfamily. They …

PPAR‐δ in Vascular Pathophysiology

N Wang - PPAR research, 2008 - Wiley Online Library
Peroxisome proliferator‐activated receptors belong to the superfamily of ligand‐dependent
nuclear receptor transcription factors, which include three subtypes: PPAR‐α, β/δ, and γ …

The role of PPARs in atherosclerosis

C Duval, G Chinetti, F Trottein, JC Fruchart… - Trends in molecular …, 2002 - cell.com
Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors
that regulate lipid and lipoprotein metabolism, glucose homeostasis and inflammation. The …

Peroxisome proliferator-activated receptor γ and atherosclerosis

N Marx - Current hypertension reports, 2002 - Springer
Within the past couple of years, peroxisome proliferator-activated receptor γ (PPARγ), a
nuclear transcription factor expressed in vascular cells, has received growing interest in …

The vascular biology of peroxisome proliferator-activated receptors: Modulation of atherosclerosis

S Verma, PE Szmitko - Canadian Journal of Cardiology, 2006 - Elsevier
Accumulating evidence suggests that peroxisome proliferator-activated receptor (PPAR)
agonists possess powerful antiatherosclerotic properties, by both directly affecting the …

PPAR-δ: A key nuclear receptor in vascular function and remodeling

L Xiao, N Wang - Journal of Molecular and Cellular Cardiology, 2022 - Elsevier
Vascular function is critical for the maintenance of body's homeostasis and is tightly
regulated by complex interactions among the vessel wall, hemodynamics, neuro-endocrine …

Targeting PPARs for therapy of atherosclerosis: A review

M Miao, X Wang, T Liu, YJ Li, WQ Yu, TM Yang… - International journal of …, 2023 - Elsevier
Atherosclerosis, a chief pathogenic factor of cardiovascular disease, is associated with many
factors including inflammation, dyslipidemia, and oxidative stress. Peroxisome proliferator …

Peroxisome proliferator-activated receptor-γ in vascular biology

J Li, N Wang - … Disorders-Drug Targets (Formerly Current Drug …, 2007 - ingentaconnect.com
Peroxisome proliferator-activated receptor-γ (PPAR-γ) belongs to a family of ligand-activated
nuclear receptor and transcription factors. The essential roles of PPAR-γ in controlling …