Hyperimmune Plasma and Immunoglobulins against COVID-19: a narrative review

M Franchini, D Focosi - Life, 2024 - mdpi.com
Since late 2019, the new SARS-CoV-2 virus belonging to the Coronaviridae family has been
responsible for COVID-19 pandemic, a severe acute respiratory syndrome. Several antiviral …

The road towards polyclonal anti-SARS-CoV-2 immunoglobulins (hyperimmune serum) for passive immunization in COVID-19

D Focosi, M Tuccori, M Franchini - Life, 2021 - mdpi.com
Effective treatments specific for COVID-19 are still lacking. In the setting of passive
immunotherapies based on neutralizing antibodies (nAbs), randomized controlled trials of …

Reduced neutralization of SARS-CoV-2 variants by convalescent plasma and hyperimmune intravenous immunoglobulins for treatment of COVID-19

J Tang, Y Lee, S Ravichandran, G Grubbs, C Huang… - bioRxiv, 2021 - biorxiv.org
ABSTRACT Hyperimmune immunoglobulin (hCoV-2IG) preparations generated from SARS-
CoV-2 convalescent plasma (CP) are under evaluation in several clinical trials of …

[PDF][PDF] Immunoglobulins or convalescent plasma to tackle COVID-19: buying time to save lives–current situation and perspectives

A Tamburello, M Marando - Swiss medical weekly, 2020 - smw.ch
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), appeared in December 2019 in Wuhan, China and is now a …

COVID-19 and Hyperimmune sera: A feasible plan B to fight against coronavirus

CBP da Costa, FJ Martins, LER da Cunha… - International …, 2021 - Elsevier
Since the very beginning of the COVID-19 pandemic, different treatment strategies have
been explored. These mainly involve the development of antimicrobial, antiviral, and/or anti …

[HTML][HTML] Functional antibodies in COVID-19 convalescent plasma

JD Herman, C Wang, C Loos, H Yoon, J Rivera… - Medrxiv, 2021 - ncbi.nlm.nih.gov
In the absence of an effective vaccine or monoclonal therapeutic, transfer of convalescent
plasma (CCP) was proposed early in the SARS-CoV-2 pandemic as an easily accessible …

Neutralizing Antibodies in the Prevention and Treatment of COVID-19

RR Razonable, P Chen - Frontiers in immunology, 2022 - frontiersin.org
The COVID-19 therapeutic landscape rapidly evolved throughout the course of the SARS-
CoV-2 pandemic. However, the ingenuity of our community quickly coalesced to identify …

Convalescent plasma and hyperimmune globulin therapy in COVID-19

D Cagdas - Expert review of clinical immunology, 2021 - Taylor & Francis
Introduction: Severe acute respiratory syndrome causing coronavirus SARS-CoV-2
(coronavirus disease 2019 (COVID-19)) has recently resulted in the recent global pandemic …

Heterologous hyperimmune polyclonal antibodies against SARS-CoV-2: A broad coverage, affordable, and scalable potential immunotherapy for COVID-19

A Alape-Girón, A Moreira-Soto, M Arguedas… - Frontiers in …, 2021 - frontiersin.org
The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis …

Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern

J Tang, Y Lee, S Ravichandran, G Grubbs, C Huang… - IScience, 2021 - cell.com
Summary Hyperimmune immunoglobulin (hCoV-2IG) generated from SARS-CoV-2
convalescent plasma (CP) are under evaluation in clinical trials. Here we explored the …