Wnt signaling plays key roles in many aspects of development. In this review, we will briefly
describe the components of signaling pathways induced by Wnt ligands and then describe …

Wnt is a family of signaling molecules involved in embryogenesis, adult tissue repair, and
cancer. They activate canonical and noncanonical Wnt signaling cascades in target cells …

The Wnt signaling network regulates chondrocyte differentiation, proliferation, and
maturation during embryonic limb development. In this review, we summarize studies of Wnt …

The skeleton as an organ is widely distributed throughout the entire vertebrate body. Wnt
signaling has emerged to play major roles in almost all aspects of skeletal development and …

Cartilage not only plays essential roles in skeletal development and growth during pre-and
postnatal stages but also serves to provide smooth movement of skeletons throughout life …

The Wnt signalling cascades have essential roles in development, growth and homeostasis
of joints and the skeleton. Progress in basic research, particularly relating to our …

Activation and disruption of Wnt/β-catenin signaling both result in cartilage breakdown via
unknown mechanisms. Here we show that both WNT-3A and the Wnt inhibitor DKK1 …

Articular cartilage provides mechanical support for joints and is responsible for smooth and
pain free joint movement. It it the primary tissue affected in joint diseases such as …

The balance between bone formation and bone resorption controls postnatal bone
homeostasis. Research over the last decade has provided a vast amount of evidence that …

In the past twenty years, secreted signaling molecules of the Wnt family have been found to
play a central role in controlling embryonic development from hydra to human. In the …