The important role of Ca 2+ in pathogenic store-operated calcium entry (SOCE) is well-
established. Among the proteins involved in the calcium signaling pathway, Stromal …

Abstract Store-operated Ca 2+ entry (SOCE) mediated by STIM and Orai proteins is a highly
regulated and ubiquitous signaling pathway that plays an important role in various cellular …

Aims There is evidence to suggest that stromal interaction molecule 1 (STIM1) functions as a
Ca2+ sensor on the endoplasmic reticulum, leading to transduction of signals to the plasma …

The Ca 2+ sensor STIM1 is crucial for activation of store-operated Ca 2+ entry (SOCE)
through transient receptor potential canonical and Orai channels. STIM1 phosphorylation …

Orai1-dependent cat-SOC and SOCE. 8, 10 Such cat-SOC not only provides Ca2+ entry into
the cell, but can also serve as a depolarizing stimulus leading to activation of voltagegated …

Background Stromal interaction molecule 1 (STIM1)-mediated store-operated Ca 2+ entry
(SOCE) is now recognized as the main mechanism of the majority of nonexcitable cell …

Abstract Store-operated Ca2+ entry (SOCE) mediates the increase in intracellular calcium
(Ca2+) in endothelial cells (ECs) that regulates several EC functions including tissue-fluid …

Thrombin increases the cytosolic Ca2+ concentrations and induces NO production by
activating proteinase‐activated receptor 1 (PAR1) in vascular endothelial cells. The store …

ORAI and stromal interaction molecule (STIM) are store-operated channel molecules that
play essential roles in human physiology through a coupling mechanism of internal Ca 2+ …

In the adult, vascular smooth muscle cells (VSMC) are normally physiologically quiescent,
arranged circumferentially in one or more layers within blood vessel walls. Remodelling of …