Infection and blockage of indwelling urinary catheters is significant owing to its high
incidence rate and severe medical consequences. Bacterial enzymes are employed as …

Catheter-associated urinary tract infections (CAUTIs) are one of the most common
healthcare-associated infections in the US, accounting for over 1 million cases annually and …

Introduction Proteus mirabilis is a key pathobiont in catheter-associated urinary tract
infections (CA-UTIs), which is well known to form crystalline biofilms that occlude catheters …

Urease as a potential target of antimicrobial drugs has received considerable attention given
its versatile roles in microbial infection. Development of effective urease inhibitors, however …

Ureases are important in both agriculture and human health. Bacterial ureases are directly
involved in many farm-field problems and pathological conditions. Here, we report a …

A new series of arylmethylene hydrazine derivatives bearing 1, 3-dimethylbarbituric moiety
7a–o were designed, synthesized, and evaluated for their in vitro urease inhibitory activity …

In our previous report, we have identified 3, 4-dihydropyrimidine scaffold as promising class
of urease inhibitor in a structure based virtual screen (SBVS) experiment. In present study …

The enzyme urease is an essential colonizing factor of the notorious carcinogenic pathogen
Helicobacter pylori (H. pylori), conferring acid resistance to the bacterium. Recently …

A series of 32 thiourea-based urease inhibitors were synthesized and evaluated against
native bacterial enzyme and whole cells of Sporosarcina pasteurii and Proteus mirabilis …

Urease is known as a virulence factor of some pathogen in the living organism. In this study,
a novel series of phenylurea conjugated to different alkyl pyridinium were designed …