Brain-derived neurotrophic factor (BDNF) is best characterized for critical roles in neuronal
survival, differentiation, and synaptic modulation mediated by the TrkB receptor tyrosine …

Although mature neurotrophins are well described trophic factors that elicit retrograde
survival signaling, the precursor forms of neurotrophins (ie, proneurotrophins) can function …

Nerve growth factor (NGF) promotes the survival and differentiation of neurons. NGF is
initially synthesized as a precursor, proNGF, which is the predominant form in the central …

Brain‐derived neurotrophic factor (BDNF) plays a critical role in the development of the
central and peripheral nervous systems, and also in neuronal survival after injury. The …

Neurotrophins are essential for development and maintenance of the vertebrate nervous
system. Paradoxically, although mature neurotrophins promote neuronal survival by binding …

Neurotrophins are initially synthesized as larger precursors (proneurotrophins), which
undergo proteolytic cleavage to yield mature forms. Although the functions of the mature …

Neuronal growth factors regulate the survival of neurons by their survival and death-
promoting activity on distinct populations of neurons. The neurotrophins nerve growth factor …

The neurotrophin brain‐derived neurotrophic factor (BDNF) binds to two cell surface
receptors: TrkB receptors that promote neuronal survival and differentiation and p75NTR …

Nerve growth factor (NGF) has been demonstrated to support survival and differentiation of
neuronal cells. Recently, a role of NGF in neuronal apoptosis has been suggested. NGF …

Proneurotrophins bind with high affinity to p75 neurotrophin receptor (p75NTR) and lack the
capacity to bind Trk receptors, suggesting that proneurotrophins can elicit apoptosis via …