Hypovitaminosis D exacerbates the DNA damage load in human uterine fibroids, which is ameliorated by vitamin D3 treatment

M Ali, SM Shahin, NA Sabri, A Al-Hendy… - Acta Pharmacologica …, 2019 - nature.com
Uterine fibroids (UFs) are the most common benign neoplastic threat to women's health and
associated with DNA damage and genomic instability. Hypovitaminosis D is a known risk …

Diet-induced vitamin D deficiency triggers inflammation and DNA damage profile in murine myometrium

H ElHusseini, H Elkafas, M Abdelaziz… - … journal of women's …, 2018 - Taylor & Francis
Background Previously, we reported a significantly higher prevalence of uterine fibroids
(UFs) in African American women. This minority group also commonly suffers from vitamin D …

Vitamin D: mechanism of action and biological effects in uterine fibroids

D Vergara, WH Catherino, G Trojano, A Tinelli - Nutrients, 2021 - mdpi.com
Uterine fibroids (UFs) are the most common benign gynecological tumors. It was estimated
that fifty percent of women presenting with UFs has symptomatology that negatively …

Endocrine-disrupting chemicals and Vitamin D deficiency in the pathogenesis of uterine fibroids

H Elkafas, OA Badary, E Elmorsy, R Kamel… - Journal of advanced …, 2021 - journals.ekb.eg
Uterine fibroids (UFs) are the most prevalent gynecologic neoplasm, affecting 70–80% of
women over their lifespan. Although UFs are benign, they can become life-threatening and …

Vitamin D, a promising natural compound with anti-uterine fibroid characteristics

M Ali, A Al-Hendy, Q Yang - Fertility and Sterility, 2019 - fertstert.org
Uterine fibroids (UFs; leiomyomas) are benign monoclonal neoplasms of the myometrium
and represent the most common tumors in reproductive-age women worldwide. Tumors …

Vitamin D3 ameliorates DNA damage caused by developmental exposure to endocrine disruptors in the uterine myometrial stem cells of eker rats

H Elkafas, M Ali, E Elmorsy, R Kamel, WE Thompson… - Cells, 2020 - mdpi.com
Early-life exposure of the myometrium to endocrine-disrupting chemicals (EDCs) has been
shown to increase the risk of uterine fibroid (UF) prevalence in adulthood. Vitamin D3 …

A systematic review of vitamin D and fibroids: pathophysiology, prevention, and treatment

A Combs, B Singh, E Nylander, MS Islam… - Reproductive …, 2023 - Springer
Uterine fibroids are the most common tumor of reproductive-age women worldwide and
cause significant morbidity in affected women. Vitamin D has emerged as a potential therapy …

The significance of measuring vitamin D serum levels in women with uterine fibroids

M Ciebiera, M Ali, L Prince, S Zgliczyński, G Jakiel… - Reproductive …, 2021 - Springer
Uterine fibroids (UFs) are benign tumors originating from smooth muscle cells and are
considered a common pathology that affects numerous women which is a notable socio …

Vitamin D and uterine fibroids—review of the literature and novel concepts

M Ciebiera, M Włodarczyk, M Ciebiera… - International Journal of …, 2018 - mdpi.com
This article provides a detailed review of current knowledge on the role of vitamin D and its
receptor in the biology and management of uterine fibroids (UFs). Authors present ideas for …

[HTML][HTML] Role of vitamin D in uterine fibroid biology

S Brakta, JS Diamond, A Al-Hendy, MP Diamond… - Fertility and sterility, 2015 - Elsevier
Objective To provide a detailed summary of current scientific knowledge on uterine fibroids
(leiomyomas) in vitro and in in vivo animal models, as well as to postulate the potential role …